NAIP

Protein identityUniProt · HPA

UniProt accession

Q13075

Gene

NAIP

Ensembl

ENSG00000249437

Chromosome

5

Canonical length

1403 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

1403 residues, UniProt reviewed canonical sequence.

>Q13075|NAIP
     1  MATQQKASDE RISQFDHNLL PELSALLGLD AVQLAKELEE EEQKERAKMQ KGYNSQMRSE
    61  AKRLKTFVTY EPYSSWIPQE MAAAGFYFTG VKSGIQCFCC SLILFGAGLT RLPIEDHKRF
   121  HPDCGFLLNK DVGNIAKYDI RVKNLKSRLR GGKMRYQEEE ARLASFRNWP FYVQGISPCV
   181  LSEAGFVFTG KQDTVQCFSC GGCLGNWEEG DDPWKEHAKW FPKCEFLRSK KSSEEITQYI
   241  QSYKGFVDIT GEHFVNSWVQ RELPMASAYC NDSIFAYEEL RLDSFKDWPR ESAVGVAALA
   301  KAGLFYTGIK DIVQCFSCGG CLEKWQEGDD PLDDHTRCFP NCPFLQNMKS SAEVTPDLQS
   361  RGELCELLET TSESNLEDSI AVGPIVPEMA QGEAQWFQEA KNLNEQLRAA YTSASFRHMS
   421  LLDISSDLAT DHLLGCDLSI ASKHISKPVQ EPLVLPEVFG NLNSVMCVEG EAGSGKTVLL
   481  KKIAFLWASG CCPLLNRFQL VFYLSLSSTR PDEGLASIIC DQLLEKEGSV TEMCVRNIIQ
   541  QLKNQVLFLL DDYKEICSIP QVIGKLIQKN HLSRTCLLIA VRTNRARDIR RYLETILEIK
   601  AFPFYNTVCI LRKLFSHNMT RLRKFMVYFG KNQSLQKIQK TPLFVAAICA HWFQYPFDPS
   661  FDDVAVFKSY MERLSLRNKA TAEILKATVS SCGELALKGF FSCCFEFNDD DLAEAGVDED
   721  EDLTMCLMSK FTAQRLRPFY RFLSPAFQEF LAGMRLIELL DSDRQEHQDL GLYHLKQINS
   781  PMMTVSAYNN FLNYVSSLPS TKAGPKIVSH LLHLVDNKES LENISENDDY LKHQPEISLQ
   841  MQLLRGLWQI CPQAYFSMVS EHLLVLALKT AYQSNTVAAC SPFVLQFLQG RTLTLGALNL
   901  QYFFDHPESL SLLRSIHFPI RGNKTSPRAH FSVLETCFDK SQVPTIDQDY ASAFEPMNEW
   961  ERNLAEKEDN VKSYMDMQRR ASPDLSTGYW KLSPKQYKIP CLEVDVNDID VVGQDMLEIL
  1021  MTVFSASQRI ELHLNHSRGF IESIRPALEL SKASVTKCSI SKLELSAAEQ ELLLTLPSLE
  1081  SLEVSGTIQS QDQIFPNLDK FLCLKELSVD LEGNINVFSV IPEEFPNFHH MEKLLIQISA
  1141  EYDPSKLVKL IQNSPNLHVF HLKCNFFSDF GSLMTMLVSC KKLTEIKFSD SFFQAVPFVA
  1201  SLPNFISLKI LNLEGQQFPD EETSEKFAYI LGSLSNLEEL ILPTGDGIYR VAKLIIQQCQ
  1261  QLHCLRVLSF FKTLNDDSVV EIAKVAISGG FQKLENLKLS INHKITEEGY RNFFQALDNM
  1321  PNLQELDISR HFTECIKAQA TTVKSLSQCV LRLPRLIRLN MLSWLLDADD IALLNVMKER
  1381  HPQSKYLTIL QKWILPFSPI IQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAIP.

Disease | ImmuneIEDB

Conditions an epitope on NAIP was assayed in.

• melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

0.41

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• defense response to bacterium
• detection of bacterium
• icosanoid biosynthetic process
• innate immune response
• negative regulation of apoptotic process
• negative regulation of neuron apoptotic process
• negative regulation of tumor necrosis factor-mediated signaling pathway
• nervous system development
• pattern recognition receptor signaling pathway
• positive regulation of inflammatory response
• positive regulation of interleukin-1 beta production
• positive regulation of JNK cascade
• pyroptotic inflammatory response
• regulation of apoptotic process

Molecular functions

• ATP binding
• cysteine-type endopeptidase inhibitor activity
• cysteine-type endopeptidase inhibitor activity involved in apoptotic process
• metal ion binding
• protein serine/threonine kinase binding

Cellular components

• basolateral plasma membrane
• canonical inflammasome complex
• cytoplasm
• IPAF inflammasome complex

Protein domainsUniProt · Pfam · InterPro

• BIR repeat
• AAA+ ATPase domain
• NACHT nucleoside triphosphatase
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NLRC4, helical domain
• Nlrc4-like, winged helix domain
• Inhibitor of Apoptosis domain
• NACHT domain
• NLRC4 helical domain
• Nlrc4-like, winged helix domain
• Baculoviral IAP repeat-containing protein 1

KeywordsUniProt

• Apoptosis
• ATP-binding
• Immunity
• Inflammatory response
• Innate immunity
• Metal-binding
• Nucleotide-binding
• Protease inhibitor
• Repeat
• Thiol protease inhibitor
• Zinc