Seroatlas · Human Serome Atlas

RABL2A

Rab-like protein 2A

Also known as: RBL2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBK7
Gene
RABL2A
Ensembl
ENSG00000144134
Chromosome
2
Canonical length
228 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Centrosome,Basal body

OverviewNCBI Gene

This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q9UBK7|RABL2A
     1  MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK
    61  HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR
   121  EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY
   181  KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABL2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 20 nTPM
  • retina: 5.9 nTPM
  • basal ganglia: 5.7 nTPM
  • choroid plexus: 5.3 nTPM
  • cerebellum: 5.1 nTPM
  • cerebral cortex: 5.1 nTPM

Single-cell type

  • ependymal cells: 223 nCPM
  • respiratory ciliated cells: 208 nCPM
  • fallopian tube ciliated cells: 159 nCPM
  • choroid plexus epithelial cells: 125 nCPM
  • epididymal efferent duct ciliated cells: 92 nCPM
  • endometrial ciliated cells: 88 nCPM

Immune cell

  • NK-cell: 14 nTPM
  • memory CD4 T-cell: 10 nTPM
  • plasmacytoid DC: 10 nTPM
  • naive B-cell: 9.6 nTPM
  • memory B-cell: 9.1 nTPM
  • myeloid DC: 8.2 nTPM

Brain region

  • midbrain: 9 nTPM
  • choroid plexus: 8.4 nTPM
  • spinal cord: 6.1 nTPM
  • medulla oblongata: 6 nTPM
  • cerebral cortex: 5.5 nTPM
  • hippocampal formation: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABL2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABL2A as an antibody target. Whether an autoantibody or antibody against RABL2A could matter depends on whether native RABL2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABL2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABL2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RABL2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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