Seroatlas · Human Serome Atlas

KIF18B

Kinesin-like protein KIF18B

Also known as: KI18B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86Y91
Gene: KIF18B
Ensembl: ENSG00000186185
Chromosome: 17
Canonical length: 852 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nuclear bodies,Microtubule ends,Cytosol

OverviewNCBI Gene

Enables cytoskeletal motor activity and kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q86Y91|KIF18B
     1  MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP GLKWGGTHDG
    61  PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG YNCSVFAYGA TGAGKTHTML
   121  GREGDPGIMY LTTVELYRRL EARQQEKHFE VLISYQEVYN EQIHDLLEPK GPLAIREDPD
   181  KGVVVQGLSF HQPASAEQLL EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG
   241  LTQAVQVAKM SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
   301  VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE IRLSLKSNVT
   361  SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD LPGSPKSGPP PEHQPCTPEL
   421  PAGPRALQEE SLGMEAQVER AMEGNSSDQE QSPEDEDEGP AEEVPTQMPE QNPTHALPES
   481  PRLTLQPKPV VGHFSARELD GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ
   541  QLVQEEKIEP GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
   601  SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ RQSFLPCLRR
   661  GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP LGPSAMQNCS TPLALPTRDL
   721  NATFDLSEEP PSKPSFHECI GWDKIPQELS RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS
   781  ACKKKRVASS SVSHGRSRIA RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR
   841  ALSAGNGVTK VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF18B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

thymus: 13 nTPM
bone marrow: 12 nTPM
lymph node: 5.3 nTPM
esophagus: 4.8 nTPM
tonsil: 4.5 nTPM
appendix: 3.5 nTPM

Single-cell type

monocyte progenitors: 74 nCPM
erythrocyte progenitors: 64 nCPM
megakaryocyte progenitors: 40 nCPM
neutrophil progenitors: 27 nCPM
differentiating spermatogonia: 23 nCPM
enteric transient amplifying cells: 23 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

midbrain: 3.1 nTPM
cerebellum: 2.2 nTPM
thalamus: 2 nTPM
pons: 1.9 nTPM
medulla oblongata: 1.7 nTPM
basal ganglia: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.48
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF18B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF18B as an antibody target. Whether an autoantibody or antibody against KIF18B could matter depends on whether native KIF18B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF18B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF18B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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