Seroatlas · Human Serome Atlas

RAB28

Ras-related protein Rab-28

Also known as: RAB28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51157
Gene
RAB28
Ensembl
ENSG00000157869
Chromosome
4
Canonical length
221 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Rab subfamily of Ras-related small GTPases. The encoded protein may be involved in regulating intracellular trafficking. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 9 and X. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P51157|RAB28
     1  MSDSEEESQD RQLKIVVLGD GASGKTSLTT CFAQETFGKQ YKQTIGLDFF LRRITLPGNL
    61  NVTLQIWDIG GQTIGGKMLD KYIYGAQGVL LVYDITNYQS FENLEDWYTV VKKVSEESET
   121  QPLVALVGNK IDLEHMRTIK PEKHLRFCQE NGFSSHFVSA KTGDSVFLCF QKVAAEILGI
   181  KLNKAEIEQS QRVVKADIVN YNQEPMSRTV NPPRSSMCAV Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • retina: 51 nTPM
  • testis: 35 nTPM
  • heart muscle: 28 nTPM
  • midbrain: 24 nTPM
  • spinal cord: 24 nTPM
  • parathyroid gland: 22 nTPM

Single-cell type

  • somatotrophs: 333 nCPM
  • pituitary stem cells: 306 nCPM
  • lactotrophs: 304 nCPM
  • thyrotrophs: 291 nCPM
  • choroid plexus epithelial cells: 250 nCPM
  • pituicytes/fscs: 238 nCPM

Immune cell

  • eosinophil: 26 nTPM
  • basophil: 21 nTPM
  • NK-cell: 21 nTPM
  • naive CD4 T-cell: 20 nTPM
  • memory B-cell: 19 nTPM
  • naive B-cell: 18 nTPM

Brain region

  • cerebellum: 83 nTPM
  • hypothalamus: 62 nTPM
  • white matter: 60 nTPM
  • midbrain: 56 nTPM
  • cerebral cortex: 56 nTPM
  • choroid plexus: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB28.

Disease | AllUniProt

Conditions RAB28 is implicated in, by any mechanism.

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 219 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.02
gnomAD missense Z
0.38
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB28 as an antibody target. Whether an autoantibody or antibody against RAB28 could matter depends on whether native RAB28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB28 is annotated at the cell surface, where native RAB28 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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