Seroatlas · Human Serome Atlas

DDX6

Probable ATP-dependent RNA helicase DDX6

Also known as: DDX6_HUMAN, HLR2, RCK, Rck/p54

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26196
Gene
DDX6
Ensembl
ENSG00000110367
Chromosome
11
Canonical length
483 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>P26196|DDX6
     1  MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT INNGTQQQAQ
    61  SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS
   121  PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV
   181  SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV
   241  QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
   301  MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS
   361  CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH
   421  RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED
   481  EKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 65 nTPM
  • tonsil: 57 nTPM
  • thymus: 51 nTPM
  • lymph node: 46 nTPM
  • retina: 45 nTPM
  • spleen: 43 nTPM

Single-cell type

  • neutrophils: 379 nCPM
  • neutrophil progenitors: 267 nCPM
  • nk-cells: 245 nCPM
  • b-cells: 235 nCPM
  • t-cells: 222 nCPM
  • innate lymphoid cells: 210 nCPM

Immune cell

  • neutrophil: 19 nTPM
  • basophil: 14 nTPM
  • eosinophil: 13 nTPM
  • non-classical monocyte: 13 nTPM
  • MAIT T-cell: 12 nTPM
  • naive CD4 T-cell: 12 nTPM

Brain region

  • cerebellum: 150 nTPM
  • white matter: 124 nTPM
  • hypothalamus: 122 nTPM
  • basal ganglia: 120 nTPM
  • cerebral cortex: 114 nTPM
  • spinal cord: 110 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX6.

Disease | AllUniProt

Conditions DDX6 is implicated in, by any mechanism.

  • Intellectual developmental disorder with impaired language and dysmorphic facies (IDDILF) MIM:618653

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder with impaired language and dysmorphic facies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
3.78
DepMap mean gene effect
-0.8
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX6 as an antibody target. Whether an autoantibody or antibody against DDX6 could matter depends on whether native DDX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDX6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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