Seroatlas · Human Serome Atlas

GBP2

Guanylate-binding protein 2

Also known as: GBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32456
Gene
GBP2
Ensembl
ENSG00000162645
Chromosome
1
Canonical length
591 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>P32456|GBP2
     1  MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG
    61  KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI
   121  LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL
   181  RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA
   241  PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN
   301  AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER
   361  EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV
   421  KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL
   481  SEKEKAIEVE RIKAESAEAA KKMLEEIQKK NEEMMEQKEK SYQEHVKQLT EKMERDRAQL
   541  MAEQEKTLAL KLQEQERLLK EGFENESKRL QKDIWDIQMR SKSLEPICNI L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 31 nTPM
  • appendix: 30 nTPM
  • smooth muscle: 30 nTPM
  • parathyroid gland: 26 nTPM
  • endometrium: 26 nTPM
  • lymph node: 25 nTPM

Single-cell type

  • neutrophils: 832 nCPM
  • endometrial luminal cells: 316 nCPM
  • monocytes: 297 nCPM
  • epididymal basal cells: 285 nCPM
  • breast secretory cells: 213 nCPM
  • schwann cells: 191 nCPM

Immune cell

  • neutrophil: 140 nTPM
  • T-reg: 79 nTPM
  • non-classical monocyte: 78 nTPM
  • MAIT T-cell: 43 nTPM
  • intermediate monocyte: 43 nTPM
  • gdT-cell: 35 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • thalamus: 9.7 nTPM
  • pons: 8 nTPM
  • hypothalamus: 6.2 nTPM
  • white matter: 4.6 nTPM
  • cerebral cortex: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBP2 as an antibody target. Whether an autoantibody or antibody against GBP2 could matter depends on whether native GBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GBP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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