Seroatlas · Human Serome Atlas

SRL

Sarcalumenin

Also known as: SAR, SRCA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TD4
Gene: SRL
Ensembl: ENSG00000185739
Chromosome: 16
Canonical length: 473 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within response to muscle activity involved in regulation of muscle adaptation. Predicted to be located in sarcoplasmic reticulum lumen and sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q86TD4|SRL
     1  MRALVLLGCL LASLLFSGQA EETEDANEEA PLRDRSHIEK TLMLNEDKPS DDYSAVLQRL
    61  RKIYHSSIKP LEQSYKYNEL RQHEITDGEI TSKPMVLFLG PWSVGKSTMI NYLLGLENTR
   121  YQLYTGAEPT TSEFTVLMHG PKLKTIEGIV MAADSARSFS PLEKFGQNFL EKLIGIEVPH
   181  KLLERVTFVD TPGIIENRKQ QERGYPFNDV CQWFIDRADL IFVVFDPTKL DVGLELEMLF
   241  RQLKGRESQI RIILNKADNL ATQMLMRVYG ALFWSLAPLI NVTEPPRVYV SSFWPQEYKP
   301  DTHQELFLQE EISLLEDLNQ VIENRLENKI AFIRQHAIRV RIHALLVDRY LQTYKDKMTF
   361  FSDGELVFKD IVEDPDKFYI FKTILAKTNV SKFDLPNREA YKDFFGINPI SSFKLLSQQC
   421  SYMGGCFLEK IERAITQELP GLLGSLGLGK NPGALNCDKT GCSETPKNRY RKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 478 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 478 nTPM
tongue: 357 nTPM
heart muscle: 264 nTPM
blood vessel: 15 nTPM
esophagus: 9 nTPM
retina: 7.9 nTPM

Single-cell type

myonuclei: 627 nCPM
thymic myoid cells: 137 nCPM
vascular smooth muscle cells: 102 nCPM
cardiomyocytes: 93 nCPM
rod photoreceptor cells: 53 nCPM
pericytes: 33 nCPM

Immune cell

basophil: 0.5 nTPM
eosinophil: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 2.8 nTPM
midbrain: 2.2 nTPM
hypothalamus: 2.1 nTPM
medulla oblongata: 2.1 nTPM
thalamus: 1.9 nTPM
amygdala: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

store-operated calcium entry

Molecular functions

GTP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRL as an antibody target. Whether an autoantibody or antibody against SRL could matter depends on whether native SRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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