Seroatlas · Human Serome Atlas

SULT1C3

Sulfotransferase 1C3

Also known as: ST1C3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IMI6
Gene: SULT1C3
Ensembl: ENSG00000196228
Chromosome: 2
Canonical length: 304 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cholesterol metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q6IMI6|SULT1C3
     1  MAKIEKNAPT MEKKPELFNI MEVDGVPTLI LSKEWWEKVC NFQAKPDDLI LATYPKSGTT
    61  WMHEILDMIL NDGDVEKCKR AQTLDRHAFL ELKFPHKEKP DLEFVLEMSS PQLIKTHLPS
   121  HLIPPSIWKE NCKIVYVARN PKDCLVSYYH FHRMASFMPD PQNLEEFYEK FMSGKVVGGS
   181  WFDHVKGWWA AKDMHRILYL FYEDIKKDPK REIEKILKFL EKDISEEILN KIIYHTSFDV
   241  MKQNPMTNYT TLPTSIMDHS ISPFMRKGMP GDWKNYFTVA QNEEFDKDYQ KKMAGSTLTF
   301  RTEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1C3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 267 nTPM

Expression across tissuesHPA

Tissue

breast: 267 nTPM
small intestine: 8 nTPM
duodenum: 2.6 nTPM
stomach: 1.1 nTPM
skin: 1 nTPM
rectum: 0.6 nTPM

Single-cell type

enterocytes: 18 nCPM
adipocytes: 13 nCPM
goblet cells: 6.1 nCPM
loop of henle epithelial cells: 5.2 nCPM
foveolar cells: 3.7 nCPM
esophageal apical cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3.5 nTPM
white matter: 0.9 nTPM
midbrain: 0.8 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.7 nTPM
basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1C3 as an antibody target. Whether an autoantibody or antibody against SULT1C3 could matter depends on whether native SULT1C3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1C3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1C3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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