ZGRF1

Protein identityUniProt · HPA

UniProt accession

Q86YA3

Gene

ZGRF1

Ensembl

ENSG00000138658

Chromosome

4

Canonical length

2104 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

2104 residues, UniProt reviewed canonical sequence.

>Q86YA3|ZGRF1
     1  MESQEFIVLY THQKMKKSKV WQDGILKITH LGNKAILYDD KGACLESLFL KCLEVKPGDD
    61  LESDRYLITV EEVKVAGAIG IVKQNVNKEA PELNSRTFIS SGRSLGCQPS GLKRKFTGFQ
   121  GPRQVPKKMV IMESGESAAS HEAKKTGPTI FSPFCSMPPL FPTVGKKDVN NILADPENIV
   181  TYKNRERNAM DFSSVFSPSF QINPEVLCEE NYFCSPVNSG NKLSDSLLTN EPVKRDSLAS
   241  HYSGVSQNIR SKAQILALLK SESSSSCEEL NSEMTEHFPQ KQPQGSLKIA TKPKYLIQQE
   301  ECAEMKSTEN LYYQHQSENT MRNKSRWAMY LSSQSSPIHS STVDGNDTER KPKAQEDDVN
   361  SNLKDLSLQK IIQFVETYAE ERKKYNVDQS VGNNDPSWNQ EVKLEIPSFN ESSSLQVTCS
   421  SAENDGILSE SDIQEDNKIP FNQNDKGCIK GSVLIKENAQ EVNTCGTLEK EYEQSESSLP
   481  ELKHLQIESS NNSRISDDIT DMISESKMDN ESLNSIHESL SNVTQPFLEV TFNLNNFETS
   541  DTEEESQESN KISQDSESWV KDILVNDGNS CFQKRSENTN CEEIEGEHLP FLTSVSDKPT
   601  VTFPVKETLP SQFCDKTYVG FDMGICKTEN TGKEIEEYSD TLSNFESFKW TDAVYGDNKE
   661  DANKPIQEVR INYDFALPPN KSKGINMNLH IPHIQNQIAE NSNLFSEDAQ PQPFILGSDL
   721  DKNDEHVLPS TSSSDNSVQL LNTNQNHYEC IALDKSNTHI SNSLFYPLGK KHLISKDTEA
   781  HISEPEDLGK IRSPPPDHVE VETAREGKQY WNPRNSSELS GLVNTISILK SLCEHSTALD
   841  SLEILKKKNT VFQQGTQQTY EPDSPPEVRK PFITVVSPKS PHLHKDSQQI LKEDEVELSE
   901  PLQSVQFSSS GSKEETAFQA VIPKQIERKT CDPKPVEFQG HQVKGSATSG VMVRGHSSQL
   961  GCSQFPDSTE YENFMTETPE LPSTCMQIDF LQVTSPEENI STLSPVSTFS LNSRDEDFMV
  1021  EFSETSLKAR TLPDDLHFLN LEGMKKSRSL ENENLQRLSL LSRTQVPLIT LPRTDGPPDL
  1081  DSHSYMINSN TYESSGSPML NLCEKSAVLS FSIEPEDQNE TFFSEESREV NPGDVSLNNI
  1141  STQSKWLKYQ NTSQCNVATP NRVDKRITDG FFAEAVSGMH FRDTSERQSD AVNESSLDSV
  1201  HLQMIKGMLY QQRQDFSSQD SVSRKKVLSL NLKQTSKTEE IKNVLGGSTC YNYSVKDLQE
  1261  ISGSELCFPS GQKIKSAYLP QRQIHIPAVF QSPAHYKQTF TSCLIEHLNI LLFGLAQNLQ
  1321  KALSKVDISF YTSLKGEKLK NAENNVPSCH HSQPAKLVMV KKEGPNKGRL FYTCDGPKAD
  1381  RCKFFKWLED VTPGYSTQEG ARPGMVLSDI KSIGLYLRSQ KIPLYEECQL LVRKGFDFQR
  1441  KQYGKLKKFT TVNPEFYNEP KTKLYLKLSR KERSSAYSKN DLWVVSKTLD FELDTFIACS
  1501  AFFGPSSINE IEILPLKGYF PSNWPTNMVV HALLVCNAST ELTTLKNIQD YFNPATLPLT
  1561  QYLLTTSSPT IVSNKRVSKR KFIPPAFTNV STKFELLSLG ATLKLASELI QVHKLNKDQA
  1621  TALIQIAQMM ASHESIEEVK ELQTHTFPIT IIHGVFGAGK SYLLAVVILF FVQLFEKSEA
  1681  PTIGNARPWK LLISSSTNVA VDRVLLGLLS LGFENFIRVG SVRKIAKPIL PYSLHAGSEN
  1741  ESEQLKELHA LMKEDLTPTE RVYVRKSIEQ HKLGTNRTLL KQVRVVGVTC AACPFPCMND
  1801  LKFPVVVLDE CSQITEPASL LPIARFECEK LILVGDPKQL PPTIQGSDAA HENGLEQTLF
  1861  DRLCLMGHKP ILLRTQYRCH PAISAIANDL FYKGALMNGV TEIERSPLLE WLPTLCFYNV
  1921  KGLEQIERDN SFHNVAEATF TLKLIQSLIA SGIAGSMIGV ITLYKSQMYK LCHLLSAVDF
  1981  HHPDIKTVQV STVDAFQGAE KEIIILSCVR TRQVGFIDSE KRMNVALTRG KRHLLIVGNL
  2041  ACLRKNQLWG RVIQHCEGRE DGLQHANQYE PQLNHLLKDY FEKQVEEKQK KKSEKEKSKD
  2101  KSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZGRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

7.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• double-strand break repair
• recombinational repair

Molecular functions

• 5'-3' DNA helicase activity
• ATP binding
• hydrolase activity
• zinc ion binding

Cellular components

• nucleus
• site of double-strand break

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, GRF-type
• P-loop containing nucleoside triphosphate hydrolase
• DNA2/NAM7 helicase, helicase domain
• DNA2/NAM7 helicase-like, C-terminal
• Upf1-like, C-terminal helicase domain
• GRF zinc finger
• AAA domain
• AAA domain
• 5'-3' DNA helicase ZGRF1-like, N-terminal domain
• DNA Repair Helicase ZGRF1
• DNA helicase ZGRF1-like, N-terminal domain

KeywordsUniProt

• ATP-binding
• DNA damage
• DNA repair
• Helicase
• Hydrolase
• Isomerase
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZGRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BRCA1