Seroatlas · Human Serome Atlas

RAB7A

Ras-related protein Rab-7a

Also known as: CMT2B, RAB7, RAB7A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51149
Gene
RAB7A
Ensembl
ENSG00000075785
Chromosome
3
Canonical length
207 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Lysosomes,Primary cilium transition zone

OverviewNCBI Gene

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>P51149|RAB7A
     1  MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ
    61  IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF
   121  VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV
   181  ELYNEFPEPI KLDKNDRAKA SAESCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
311 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 311 nTPM
  • tongue: 233 nTPM
  • choroid plexus: 214 nTPM
  • spinal cord: 181 nTPM
  • heart muscle: 175 nTPM
  • midbrain: 174 nTPM

Single-cell type

  • neutrophils: 2,579 nCPM
  • esophageal apical cells: 2,095 nCPM
  • monocytes: 1,085 nCPM
  • endometrial glandular cells: 1,035 nCPM
  • esophageal suprabasal cells: 1,004 nCPM
  • macrophages: 865 nCPM

Immune cell

  • neutrophil: 375 nTPM
  • eosinophil: 214 nTPM
  • non-classical monocyte: 205 nTPM
  • total PBMC: 201 nTPM
  • myeloid DC: 200 nTPM
  • basophil: 196 nTPM

Brain region

  • cerebral cortex: 285 nTPM
  • white matter: 236 nTPM
  • pons: 209 nTPM
  • medulla oblongata: 202 nTPM
  • hypothalamus: 201 nTPM
  • thalamus: 201 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB7A.

Disease | AllUniProt

Conditions RAB7A is implicated in, by any mechanism.

  • Charcot-Marie-Tooth disease, axonal, type 2B (CMT2B) MIM:600882

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 214 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
2.28
DepMap mean gene effect
-0.57
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB7A as an antibody target. Whether an autoantibody or antibody against RAB7A could matter depends on whether native RAB7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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