Seroatlas · Human Serome Atlas

RABL3

Rab-like protein 3

Also known as: MGC23920, RABL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5HYI8
Gene
RABL3
Ensembl
ENSG00000144840
Chromosome
3
Canonical length
236 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in regulation of Ras protein signal transduction and regulation of protein lipidation. Predicted to be active in endomembrane system. Implicated in pancreatic cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q5HYI8|RABL3
     1  MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY KEGTPEEKTY
    61  YIELWDVGGS VGSASSVKST RAVFYNSVNG IIFVHDLTNK KSSQNLRRWS LEALNRDLVP
   121  TGVLVTNGDY DQEQFADNQI PLLVIGTKLD QIHETKRHEV LTRTAFLAED FNPEEINLDC
   181  TNPRYLAAGS SNAVKLSRFF DKVIEKRYFL REGNQIPGFP DRKRFGAGTL KSLHYD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 12 nTPM
  • parathyroid gland: 11 nTPM
  • tongue: 11 nTPM
  • adipose tissue: 10 nTPM
  • kidney: 9.2 nTPM
  • liver: 9.1 nTPM

Single-cell type

  • cone photoreceptor cells: 201 nCPM
  • retinal bipolar cells: 61 nCPM
  • late primary spermatocytes: 58 nCPM
  • adrenal cortex cells: 50 nCPM
  • endometrial ciliated cells: 49 nCPM
  • esophageal apical cells: 46 nCPM

Immune cell

  • myeloid DC: 6.6 nTPM
  • NK-cell: 5.7 nTPM
  • intermediate monocyte: 5.6 nTPM
  • T-reg: 5.3 nTPM
  • memory CD8 T-cell: 5.1 nTPM
  • gdT-cell: 4.6 nTPM

Brain region

  • white matter: 8.1 nTPM
  • medulla oblongata: 6.9 nTPM
  • hypothalamus: 6.7 nTPM
  • midbrain: 6.1 nTPM
  • spinal cord: 6 nTPM
  • cerebellum: 5.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RABL3.

Disease | AllUniProt

Conditions RABL3 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABL3 as an antibody target. Whether an autoantibody or antibody against RABL3 could matter depends on whether native RABL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RABL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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