Seroatlas · Human Serome Atlas

DNM3

Dynamin-3

Also known as: DYN3_HUMAN, KIAA0820

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQ16
Gene
DNM3
Ensembl
ENSG00000197959
Chromosome
1
Canonical length
869 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

869 residues, UniProt reviewed canonical sequence.

>Q9UQ16|DNM3
     1  MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG
    61  SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRLE IEAETDRVTG MNKGISSIPI
   121  NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIREMI MQFITRENCL ILAVTPANTD
   181  LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK
   241  DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL
   301  QGQLLSIEHE VEAYKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA
   361  KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL
   421  KGPSLKSVDL VIQELINTVK KCTKKLANFP RLCEETERIV ANHIREREGK TKDQVLLLID
   481  IQVSYINTNH EDFIGFANAQ QRSSQVHKKT TVGNQGTNLP PSRQIVIRKG WLTISNIGIM
   541  KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKSFMSSKH IFALFNTEQR
   601  NVYKDYRFLE LACDSQEDVD SWKASLLRAG VYPDKSVAEN DENGQAENFS MDPQLERQVE
   661  TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESAE
   721  QAQRRDEMLR MYQALKEALG IIGDISTATV STPAPPPVDD SWIQHSRRSP PPSPTTQRRP
   781  TLSAPLARPT SGRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPSSSDSFGA PPQVPSRPTR
   841  APPSVPSRRP PPSPTRPTII RPLESSLLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 40 nTPM
  • cerebral cortex: 23 nTPM
  • spinal cord: 22 nTPM
  • midbrain: 19 nTPM
  • hypothalamus: 19 nTPM
  • hippocampal formation: 17 nTPM

Single-cell type

  • oligodendrocytes: 2,117 nCPM
  • oligodendrocyte progenitor cells: 1,327 nCPM
  • lactotrophs: 834 nCPM
  • brain excitatory neurons: 807 nCPM
  • platelets: 764 nCPM
  • brain inhibitory neurons: 732 nCPM

Immune cell

  • total PBMC: 1 nTPM
  • T-reg: 0.8 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • white matter: 214 nTPM
  • cerebellum: 190 nTPM
  • pons: 181 nTPM
  • medulla oblongata: 166 nTPM
  • hypothalamus: 150 nTPM
  • thalamus: 148 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0
gnomAD missense Z
2.7
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNM3 as an antibody target. Whether an autoantibody or antibody against DNM3 could matter depends on whether native DNM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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