Seroatlas · Human Serome Atlas

PSMC2

26S proteasome regulatory subunit 7

Also known as: MSS1, Nbla10058, PRS7_HUMAN, RPT1, S7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35998
Gene
PSMC2
Ensembl
ENSG00000161057
Chromosome
7
Canonical length
433 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>P35998|PSMC2
     1  MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN
    61  ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK
   121  FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC
   181  KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV
   241  IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
   301  ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR
   361  SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY
   421  AKFSATPRYM TYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 88 nTPM
  • tongue: 72 nTPM
  • liver: 51 nTPM
  • thymus: 40 nTPM
  • parathyroid gland: 39 nTPM
  • kidney: 37 nTPM

Single-cell type

  • syncytiotrophoblasts: 288 nCPM
  • cytotrophoblasts: 217 nCPM
  • epicardial cells: 202 nCPM
  • late primary spermatocytes: 184 nCPM
  • hofbauer cells: 178 nCPM
  • migrating cytotrophoblasts: 160 nCPM

Immune cell

  • basophil: 141 nTPM
  • non-classical monocyte: 99 nTPM
  • T-reg: 94 nTPM
  • intermediate monocyte: 82 nTPM
  • myeloid DC: 75 nTPM
  • total PBMC: 74 nTPM

Brain region

  • white matter: 32 nTPM
  • choroid plexus: 31 nTPM
  • spinal cord: 30 nTPM
  • cerebellum: 29 nTPM
  • cerebral cortex: 28 nTPM
  • hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
3.62
DepMap mean gene effect
-1.48
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMC2 as an antibody target. Whether an autoantibody or antibody against PSMC2 could matter depends on whether native PSMC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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