Seroatlas · Human Serome Atlas

SEPTIN2

Septin-2

Also known as: DIFF6, hNedd5, KIAA0158, NEDD5, Pnutl3, SEPT2, SEPT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15019
Gene
SEPTIN2
Ensembl
ENSG00000168385
Chromosome
2
Canonical length
361 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Microtubules,Cytokinetic bridge,Primary cilium,Principal piece,Annulus

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; cytoskeleton-dependent cytokinesis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q15019|SEPTIN2
     1  MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK STLINSLFLT
    61  DLYPERVIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV DTPGYGDAIN CRDCFKTIIS
   121  YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL KPLDVAFMKA IHNKVNIVPV
   181  IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV
   241  GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR
   301  SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG DGDGGALGHH
   361  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
264 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 264 nTPM
  • smooth muscle: 236 nTPM
  • adipose tissue: 231 nTPM
  • ovary: 230 nTPM
  • cervix: 220 nTPM
  • thyroid gland: 210 nTPM

Single-cell type

  • pituicytes/fscs: 335 nCPM
  • mast cells: 330 nCPM
  • extravillous trophoblasts: 307 nCPM
  • pancreatic acinar cells: 280 nCPM
  • lactotrophs: 277 nCPM
  • sertoli cells: 267 nCPM

Immune cell

  • total PBMC: 241 nTPM
  • NK-cell: 192 nTPM
  • intermediate monocyte: 184 nTPM
  • myeloid DC: 184 nTPM
  • basophil: 173 nTPM
  • classical monocyte: 165 nTPM

Brain region

  • white matter: 314 nTPM
  • medulla oblongata: 291 nTPM
  • spinal cord: 276 nTPM
  • basal ganglia: 252 nTPM
  • hypothalamus: 249 nTPM
  • cerebellum: 243 nTPM

ReferencesPubMed · IEDB

Publications for SEPTIN2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

3 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.29
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN2 as an antibody target. Whether an autoantibody or antibody against SEPTIN2 could matter depends on whether native SEPTIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN2 is annotated at the cell surface, where native SEPTIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SEPTIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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