Seroatlas · Human Serome Atlas

GAL3ST4

Galactose-3-O-sulfotransferase 4

Also known as: FLJ12116, G3ST4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RP7
Gene
GAL3ST4
Ensembl
ENSG00000197093
Chromosome
7
Canonical length
486 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q96RP7|GAL3ST4
     1  MGPLSPARTL RLWGPRSLGV ALGVFMTIGF ALQLLGGPFQ RRLPGLQLRQ PSAPSLRPAL
    61  PSCPPRQRLV FLKTHKSGSS SVLSLLHRYG DQHGLRFALP ARYQFGYPKL FQASRVKGYR
   121  PQGGGTQLPF HILCHHMRFN LKEVLQVMPS DSFFFSIVRD PAALARSAFS YYKSTSSAFR
   181  KSPSLAAFLA NPRGFYRPGA RGDHYARNLL WFDFGLPFPP EKRAKRGNIH PPRDPNPPQL
   241  QVLPSGAGPR AQTLNPNALI HPVSTVTDHR SQISSPASFD LGSSSFIQWG LAWLDSVFDL
   301  VMVAEYFDES LVLLADALCW GLDDVVGFMH NAQAGHKQGL STVSNSGLTA EDRQLTARAR
   361  AWNNLDWALY VHFNRSLWAR IEKYGQGRLQ TAVAELRARR EALAKHCLVG GEASDPKYIT
   421  DRRFRPFQFG SAKVLGYILR SGLSPQDQEE CERLATPELQ YKDKLDAKQF PPTVSLPLKT
   481  SRPLSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAL3ST4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • skin: 27 nTPM
  • salivary gland: 24 nTPM
  • thymus: 21 nTPM
  • blood vessel: 11 nTPM
  • vagina: 10 nTPM
  • cervix: 9.9 nTPM

Single-cell type

  • microglia: 85 nCPM
  • oligodendrocyte progenitor cells: 24 nCPM
  • macrophages: 19 nCPM
  • pituitary stem cells: 11 nCPM
  • salivary acinar cells: 11 nCPM
  • adrenal medulla cells: 11 nCPM

Immune cell

  • naive CD4 T-cell: 15 nTPM
  • plasmacytoid DC: 4.7 nTPM
  • naive CD8 T-cell: 4.6 nTPM
  • memory CD4 T-cell: 4.5 nTPM
  • total PBMC: 2.2 nTPM
  • T-reg: 1.3 nTPM

Brain region

  • thalamus: 26 nTPM
  • medulla oblongata: 21 nTPM
  • white matter: 20 nTPM
  • cerebral cortex: 16 nTPM
  • spinal cord: 16 nTPM
  • pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAL3ST4 as an antibody target. Whether an autoantibody or antibody against GAL3ST4 could matter depends on whether native GAL3ST4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAL3ST4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAL3ST4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAL3ST4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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