Seroatlas · Human Serome Atlas

DDX31

ATP-dependent DNA helicase DDX31

Also known as: DDX31_HUMAN, FLJ13633, FLJ14578, FLJ23349, PPP1R25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8H2
Gene: DDX31
Ensembl: ENSG00000125485
Chromosome: 9
Canonical length: 851 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Vesicles

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

851 residues, UniProt reviewed canonical sequence.

>Q9H8H2|DDX31
     1  MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP VPPSPAPLGT
    61  SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA SPTQTMAAAD GSLFDNPRTF
   121  SRRPPAQASR QAKATKRKYQ ASSEAPPAKR RNETSFLPAK KTSVKETQRT FKGNAQKMFS
   181  PKKHSVSTSD RNQEERQCIK TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH
   241  LISTINTVLK MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI
   301  QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK ARLRKGINIL
   361  ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK DITVILNAVN AECQKRQNVL
   421  LSATLTEGVT RLADISLHDP VSISVLDKSH DQLNPKDKAV QEVCPPPAGD KLDSFAIPES
   481  LKQHVTVVPS KLRLVCLAAF ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA
   541  PASGQLPSAS MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI
   601  VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV SEIKMEDILC
   661  VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY VHSSERRVSW AKKALQSFIQ
   721  AYATYPRELK HIFHVRSLHL GHVAKSFGLR DAPRNLSALT RKKRKAHVKR PDLHKKTQSK
   781  HSLAEILRSE YSSGMEADIA KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG
   841  VQRDSKTSQK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 10 nTPM
cerebellum: 8.9 nTPM
skin: 7.6 nTPM
salivary gland: 6.5 nTPM
ovary: 5.9 nTPM
testis: 5.7 nTPM

Single-cell type

leydig cells: 82 nCPM
oocytes: 69 nCPM
adrenal medulla cells: 64 nCPM
alveolar cells type 1: 52 nCPM
peritubular myoid cells: 44 nCPM
salivary acinar cells: 43 nCPM

Immune cell

naive CD4 T-cell: 2.7 nTPM
gdT-cell: 2.4 nTPM
memory CD4 T-cell: 2.2 nTPM
naive CD8 T-cell: 2.2 nTPM
myeloid DC: 2.1 nTPM
memory CD8 T-cell: 1.9 nTPM

Brain region

cerebellum: 18 nTPM
pons: 13 nTPM
medulla oblongata: 10 nTPM
white matter: 10 nTPM
midbrain: 9.2 nTPM
basal ganglia: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosome biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX31 as an antibody target. Whether an autoantibody or antibody against DDX31 could matter depends on whether native DDX31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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