Seroatlas · Human Serome Atlas

SULT2B1

Sulfotransferase 2B1

Also known as: HSST2, ST2B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00204
Gene: SULT2B1
Ensembl: ENSG00000088002
Chromosome: 19
Canonical length: 365 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>O00204|SULT2B1
     1  MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS LAENTQDVRD
    61  DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER APWCETIVGA FSLPDQYSPR
   121  LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL
   181  KGEVQFGSWF DHIKGWLRMK GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV
   241  VAHSTFSAMK ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ
   301  MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS PSPGQASETP
   361  HPRPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT2B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 305 nTPM

Expression across tissuesHPA

Tissue

esophagus: 305 nTPM
skin: 196 nTPM
vagina: 153 nTPM
cervix: 106 nTPM
salivary gland: 52 nTPM
tonsil: 27 nTPM

Single-cell type

esophageal apical cells: 3,869 nCPM
esophageal suprabasal cells: 1,085 nCPM
suprabasal keratinocytes: 519 nCPM
ocular epithelial cells: 217 nCPM
esophageal basal cells: 170 nCPM
respiratory secretory cells: 148 nCPM

Immune cell

MAIT T-cell: 0.6 nTPM
basophil: 0.5 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

thalamus: 1.9 nTPM
midbrain: 1.4 nTPM
cerebellum: 1.2 nTPM
amygdala: 1 nTPM
medulla oblongata: 1 nTPM
cerebral cortex: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SULT2B1.

Disease | AllUniProt

Conditions SULT2B1 is implicated in, by any mechanism.

Ichthyosis, congenital, autosomal recessive 14 (ARCI14) MIM:617571

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ichthyosis, congenital, autosomal recessive 14
Autosomal recessive congenital ichthyosis 2
Autosomal recessive congenital ichthyosis 1
Uterine corpus endometrial carcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.44
gnomAD missense Z: 1.11
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SULT2B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SULT1A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT2B1 as an antibody target. Whether an autoantibody or antibody against SULT2B1 could matter depends on whether native SULT2B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT2B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT2B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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