Seroatlas · Human Serome Atlas

GPN1

GPN-loop GTPase 1

Also known as: ATPBD1A, GPN1_HUMAN, MBDIN, NTPBP, RPAP4, XAB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCN4
Gene: GPN1
Ensembl: ENSG00000198522
Chromosome: 2
Canonical length: 374 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q9HCN4|GPN1
     1  MAASAAAAEL QASGGPRHPV CLLVLGMAGS GKTTFVQRLT GHLHAQGTPP YVINLDPAVH
    61  EVPFPANIDI RDTVKYKEVM KQYGLGPNGG IVTSLNLFAT RFDQVMKFIE KAQNMSKYVL
   121  IDTPGQIEVF TWSASGTIIT EALASSFPTV VIYVMDTSRS TNPVTFMSNM LYACSILYKT
   181  KLPFIVVMNK TDIIDHSFAV EWMQDFEAFQ DALNQETTYV SNLTRSMSLV LDEFYSSLRV
   241  VGVSAVLGTG LDELFVQVTS AAEEYEREYR PEYERLKKSL ANAESQQQRE QLERLRKDMG
   301  SVALDAGTAK DSLSPVLHPS DLILTRGTLD EEDEEADSDT DDIDHRVTEE SHEEPAFQNF
   361  MQESMAQYWK RNNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
skeletal muscle: 31 nTPM
tonsil: 28 nTPM
thymus: 28 nTPM
lymph node: 27 nTPM
tongue: 25 nTPM

Single-cell type

late spermatids: 114 nCPM
late primary spermatocytes: 95 nCPM
early spermatids: 86 nCPM
oocytes: 74 nCPM
esophageal apical cells: 61 nCPM
extravillous trophoblasts: 56 nCPM

Immune cell

NK-cell: 106 nTPM
basophil: 93 nTPM
memory CD8 T-cell: 92 nTPM
myeloid DC: 90 nTPM
MAIT T-cell: 86 nTPM
total PBMC: 82 nTPM

Brain region

medulla oblongata: 24 nTPM
midbrain: 24 nTPM
thalamus: 23 nTPM
pons: 22 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -1.7
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein import into nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPN1 as an antibody target. Whether an autoantibody or antibody against GPN1 could matter depends on whether native GPN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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