Seroatlas · Human Serome Atlas

ARL13A

ADP-ribosylation factor-like protein 13A

Also known as: AR13A_HUMAN, ARL13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H913
Gene: ARL13A
Ensembl: ENSG00000174225
Chromosome: X
Canonical length: 290 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Cytosol,Acrosome,Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in non-motile cilium assembly and receptor localization to non-motile cilium. Predicted to be active in ciliary membrane; motile cilium; and non-motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q5H913|ARL13A
     1  MFRLLSSCCS CLRTTEETRR NVTIPIIGLN NSGKTVLVEA FQKLLPSKTD HCMKSELTTL
    61  LLDEYELSIY DLNGDLKGRE AWPNYYAQAH GLVFVLDSSD IRRMQEVKII LTHLLSDKRV
   121  AGKPILILAN KQDKKKALMP CDIIDYLLLK KLVKENKCPC RVEPCSAIRN LERRNHQPIV
   181  EGLRWLLAVI DTCQLPPTSS ISISKNNTGS GERCSSHSFS TRTGMSKEKR QHLEQCSIEA
   241  KPLKSILQKE GTRLWSKKNM SVTFALDEPM KEGECSRRMR AQNTTKLCYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL13A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

testis: 4.8 nTPM
skin: 0.7 nTPM
duodenum: 0.3 nTPM
retina: 0.3 nTPM
thyroid gland: 0.3 nTPM
esophagus: 0.2 nTPM

Single-cell type

late spermatids: 89 nCPM
early spermatids: 73 nCPM
late primary spermatocytes: 38 nCPM
epicardial cells: 9.1 nCPM
retinal ganglion cells: 7.7 nCPM
cardiomyocytes: 5.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.5 nTPM
white matter: 1.9 nTPM
thalamus: 1.8 nTPM
hypothalamus: 1.5 nTPM
medulla oblongata: 1.3 nTPM
pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL13A as an antibody target. Whether an autoantibody or antibody against ARL13A could matter depends on whether native ARL13A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL13A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL13A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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