Seroatlas · Human Serome Atlas

ZNG1A

Zinc-regulated GTPase metalloprotein activator 1A

Also known as: CBWD1, ZNG1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRT8
Gene: ZNG1A
Ensembl: ENSG00000172785
Chromosome: 9
Canonical length: 395 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable GTPase activity and zinc chaperone activity. Involved in kidney development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q9BRT8|ZNG1A
     1  MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
    61  YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDSGLRAI
   121  ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
   181  EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
   241  NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
   301  KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL
   361  GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNG1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

kidney: 38 nTPM
parathyroid gland: 37 nTPM
adrenal gland: 33 nTPM
choroid plexus: 31 nTPM
pancreas: 29 nTPM
esophagus: 26 nTPM

Single-cell type

syncytiotrophoblasts: 150 nCPM
cytotrophoblasts: 124 nCPM
migrating cytotrophoblasts: 90 nCPM
megakaryocytes: 80 nCPM
paneth cells: 77 nCPM
choroid plexus epithelial cells: 73 nCPM

Immune cell

intermediate monocyte: 82 nTPM
myeloid DC: 79 nTPM
classical monocyte: 70 nTPM
non-classical monocyte: 66 nTPM
total PBMC: 51 nTPM
memory B-cell: 23 nTPM

Brain region

choroid plexus: 19 nTPM
cerebellum: 18 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 14 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

kidney development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNG1A as an antibody target. Whether an autoantibody or antibody against ZNG1A could matter depends on whether native ZNG1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNG1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNG1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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