Seroatlas · Human Serome Atlas

RIGI

Antiviral innate immune response receptor RIG-I

Also known as: DDX58, DKFZp434J1111, FLJ13599, RIG-1, RIG-I, RIG1, RIGI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95786
Gene
RIGI
Ensembl
ENSG00000107201
Chromosome
9
Canonical length
925 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

925 residues, UniProt reviewed canonical sequence.

>O95786|RIGI
     1  MTTEQRRSLQ AFQDYIRKTL DPTYILSYMA PWFREEEVQY IQAEKNNKGP MEAATLFLKF
    61  LLELQEEGWF RGFLDALDHA GYSGLYEAIE SWDFKKIEKL EEYRLLLKRL QPEFKTRIIP
   121  TDIISDLSEC LINQECEEIL QICSTKGMMA GAEKLVECLL RSDKENWPKT LKLALEKERN
   181  KFSELWIVEK GIKDVETEDL EDKMETSDIQ IFYQEDPECQ NLSENSCPPS EVSDTNLYSP
   241  FKPRNYQLEL ALPAMKGKNT IICAPTGCGK TFVSLLICEH HLKKFPQGQK GKVVFFANQI
   301  PVYEQQKSVF SKYFERHGYR VTGISGATAE NVPVEQIVEN NDIIILTPQI LVNNLKKGTI
   361  PSLSIFTLMI FDECHNTSKQ HPYNMIMFNY LDQKLGGSSG PLPQVIGLTA SVGVGDAKNT
   421  DEALDYICKL CASLDASVIA TVKHNLEELE QVVYKPQKFF RKVESRISDK FKYIIAQLMR
   481  DTESLAKRIC KDLENLSQIQ NREFGTQKYE QWIVTVQKAC MVFQMPDKDE ESRICKALFL
   541  YTSHLRKYND ALIISEHARM KDALDYLKDF FSNVRAAGFD EIEQDLTQRF EEKLQELESV
   601  SRDPSNENPK LEDLCFILQE EYHLNPETIT ILFVKTRALV DALKNWIEGN PKLSFLKPGI
   661  LTGRGKTNQN TGMTLPAQKC ILDAFKASGD HNILIATSVA DEGIDIAQCN LVILYEYVGN
   721  VIKMIQTRGR GRARGSKCFL LTSNAGVIEK EQINMYKEKM MNDSILRLQT WDEAVFREKI
   781  LHIQTHEKFI RDSQEKPKPV PDKENKKLLC RKCKALACYT ADVRVIEECH YTVLGDAFKE
   841  CFVSRPHPKP KQFSSFEKRA KIFCARQNCS HDWGIHVKYK TFEIPVIKIE SFVVEDIATG
   901  VQTLYSKWKD FHFEKIPFDP AEMSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIGI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 14 nTPM
  • salivary gland: 9.4 nTPM
  • spleen: 8.6 nTPM
  • skin: 7.4 nTPM
  • appendix: 7.1 nTPM
  • lymph node: 6.9 nTPM

Single-cell type

  • microglia: 62 nCPM
  • proximal tubule cells: 47 nCPM
  • oligodendrocyte progenitor cells: 46 nCPM
  • renal collecting duct principal cells: 41 nCPM
  • astrocytes: 37 nCPM
  • papillary tip epithelial cells: 36 nCPM

Immune cell

  • neutrophil: 1.3 nTPM
  • NK-cell: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • spinal cord: 14 nTPM
  • medulla oblongata: 12 nTPM
  • pons: 8.7 nTPM
  • midbrain: 8.2 nTPM
  • thalamus: 8.1 nTPM
  • hypothalamus: 7.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RIGI.

Disease | AllUniProt

Conditions RIGI is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 800 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Singleton-Merten syndrome 2
  • RIGI-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIGI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIGI as an antibody target. Whether an autoantibody or antibody against RIGI could matter depends on whether native RIGI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIGI is annotated at the cell surface, where native RIGI is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIGI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIGI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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