TOR2A

Protein identityUniProt · HPA

UniProt accession

Q5JU69

Gene

TOR2A

Ensembl

ENSG00000160404

Chromosome

9

Canonical length

321 aa

Protein class

Predicted secreted proteins

Subcellular location

Endoplasmic reticulum,Plasma membrane

Secretome location

Secreted to blood

Quaternary structure

Homohexamer

OverviewNCBI Gene

This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q5JU69|TOR2A
     1  MAAATRGCRP WGSLLGLLGL VSAAAAAWDL ASLRCTLGAF CECDFRPDLP GLECDLAQHL
    61  AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS YVSSLLAHYL FQGGLRSPRV
   121  HHFSPVLHFP HPSHIERYKK DLKSWVQGNL TACGRSLFLF DEMDKMPPGL MEVLRPFLGS
   181  SWVVYGTNYR KAIFIFISNT GGKQINQVAL EAWRSRRDRE EILLQELEPV ISRAVLDNPH
   241  HGFSNSGIME ERLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPRDEVVQA VLDSTTFFPE
   301  DEQLFSSNGC KTVASRIAFF L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOR2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.78

gnomAD pLI

0.14

gnomAD missense Z

0.25

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• ATP binding
• ATP hydrolysis activity
• identical protein binding

Cellular components

• endoplasmic reticulum lumen
• nuclear envelope

Protein domainsUniProt · Pfam · InterPro

• ClpA/B family
• AAA+ ATPase domain
• Torsin
• Torsin 1/2
• P-loop containing nucleoside triphosphate hydrolase
• Torsin-1A, C-terminal domain
• Torsin
• Torsin-1A, C-terminal domain

KeywordsUniProt

• ATP-binding
• Endoplasmic reticulum
• Glycoprotein
• Nucleotide-binding
• Signal

InteractionsUniProt · HPA

Protein binding partners of TOR2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TOR1AIP1