Seroatlas · Human Serome Atlas

AGAP3

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Also known as: AGAP3_HUMAN, CENTG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96P47
Gene
AGAP3
Ensembl
ENSG00000133612
Chromosome
7
Canonical length
875 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

875 residues, UniProt reviewed canonical sequence.

>Q96P47|AGAP3
     1  MNFQAGGGQS PQQQQQLAGG PPQQFALSNS AAIRAEIQRF ESVHPNIYAI YDLIERIEDL
    61  ALQNQIREHV ISIEDSFVNS QEWTLSRSVP ELKVGIVGNL SSGKSALVHR YLTGTYVQEE
   121  SPEGGRFKKE IVVDGQSYLL LIRDEGGPPE LQFAAWVDAV VFVFSLEDEI SFQTVYNYFL
   181  RLCSFRNASE VPMVLVGTQD AISAANPRVI DDSRARKLST DLKRCTYYET CATYGLNVER
   241  VFQDVAQKVV ALRKKQQLAI GPCKSLPNSP SHSAVSAASI PAVHINQATN GGGSAFSDYS
   301  SSVPSTPSIS QRELRIETIA ASSTPTPIRK QSKRRSNIFT SRKGADLDRE KKAAECKVDS
   361  IGSGRAIPIK QGILLKRSGK SLNKEWKKKY VTLCDNGLLT YHPSLHDYMQ NIHGKEIDLL
   421  RTTVKVPGKR LPRATPATAP GTSPRANGLS VERSNTQLGG GTGAPHSASS ASLHSERPLS
   481  SSAWAGPRPE GLHQRSCSVS SADQWSEATT SLPPGMQHPA SGPAEVLSSS PKLDPPPSPH
   541  SNRKKHRRKK STGTPRPDGP SSATEEAEES FEFVVVSLTG QTWHFEASTA EERELWVQSV
   601  QAQILASLQG CRSAKDKTRL GNQNAALAVQ AVRTVRGNSF CIDCDAPNPD WASLNLGALM
   661  CIECSGIHRH LGAHLSRVRS LDLDDWPPEL LAVMTAMGNA LANSVWEGAL GGYSKPGPDA
   721  CREEKERWIR AKYEQKLFLA PLPSSDVPLG QQLLRAVVED DLRLLVMLLA HGSKEEVNET
   781  YGDGDGRTAL HLSSAMANVV FTQLLIWYGV DVRSRDARGL TPLAYARRAG SQECADILIQ
   841  HGCPGEGCGL APTPNREPAN GTNPSAELHR SPSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
265 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 265 nTPM
  • hippocampal formation: 235 nTPM
  • amygdala: 220 nTPM
  • cerebellum: 188 nTPM
  • basal ganglia: 143 nTPM
  • hypothalamus: 138 nTPM

Single-cell type

  • somatotrophs: 370 nCPM
  • lactotrophs: 215 nCPM
  • thyrotrophs: 111 nCPM
  • cdc: 110 nCPM
  • monocytes: 109 nCPM
  • macrophages: 99 nCPM

Immune cell

  • classical monocyte: 2.7 nTPM
  • memory B-cell: 2 nTPM
  • NK-cell: 2 nTPM
  • intermediate monocyte: 1.7 nTPM
  • memory CD8 T-cell: 1.6 nTPM
  • total PBMC: 1.5 nTPM

Brain region

  • cerebral cortex: 299 nTPM
  • hippocampal formation: 246 nTPM
  • white matter: 220 nTPM
  • basal ganglia: 219 nTPM
  • amygdala: 213 nTPM
  • medulla oblongata: 185 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.91
gnomAD missense Z
2.99
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP3 as an antibody target. Whether an autoantibody or antibody against AGAP3 could matter depends on whether native AGAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGAP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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