TAP2

Protein identityUniProt · HPA

UniProt accession

Q03519

Gene

TAP2

Ensembl

ENSG00000204267

Chromosome

6

Canonical length

686 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Nuclear speckles,Endoplasmic reticulum

OverviewNCBI Gene

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q03519|TAP2
     1  MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG
    61  FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS
   121  PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL
   181  GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF
   241  FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM
   301  PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE
   361  QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG
   421  SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR
   481  PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC
   541  YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV
   601  GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA
   661  HRLQTVQRAH QILVLQEGKL QKLAQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

9

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

28 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAP2.

Disease | AllUniProt

Conditions TAP2 is implicated in, by any mechanism.

• MHC class I deficiency 2 (MHC1D2) MIM:620813

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 511 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• MHC class I deficiency
• MHC class I deficiency 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0

gnomAD missense Z

1.39

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antigen processing and presentation of endogenous peptide antigen via MHC class I
• antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
• antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
• cytosol to endoplasmic reticulum transport
• peptide antigen transport
• positive regulation of T cell mediated cytotoxicity
• protein transport
• response to molecule of bacterial origin
• T cell mediated cytotoxicity
• transmembrane transport
• antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

Molecular functions

• ABC-type peptide antigen transporter activity
• ABC-type peptide transporter activity
• ATP binding
• ATP hydrolysis activity
• metal ion binding
• MHC class Ib protein binding
• peptide antigen binding
• peptide transmembrane transporter activity
• TAP1 binding
• tapasin binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• endoplasmic reticulum-Golgi intermediate compartment membrane
• membrane
• MHC class I peptide loading complex
• nuclear speck
• phagocytic vesicle membrane
• TAP complex

Protein domainsUniProt · Pfam · InterPro

• ABC transporter-like, ATP-binding domain
• AAA+ ATPase domain
• ABC transporter type 1, transmembrane domain
• ABC transporter Tap-like
• ABC transporter-like, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• ABC transporter type 1, transmembrane domain superfamily
• Type 1 protein exporter
• ABC transporter
• ABC transporter transmembrane region
• Antigen peptide transporter 2

KeywordsUniProt

• Adaptive immunity
• ATP-binding
• Endoplasmic reticulum
• Host-virus interaction
• Immunity
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Peptide transport
• Protein transport
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of TAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TAP1