Seroatlas · Human Serome Atlas

IDNK

Probable gluconokinase

Also known as: bA522I20.2, C9orf103, GNTK_HUMAN, hGntK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T6J7
Gene: IDNK
Ensembl: ENSG00000148057
Chromosome: 9
Canonical length: 187 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable gluconokinase activity. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q5T6J7|IDNK
     1  MAAPGALLVM GVSGSGKSTV GALLASELGW KFYDADDYHP EENRRKMGKG IPLNDQDRIP
    61  WLCNLHDILL RDVASGQRVV LACSALKKTY RDILTQGKDG VALKCEESGK EAKQAEMQLL
   121  VVHLSGSFEV ISGRLLKREG HFMPPELLQS QFETLEPPAA PENFIQISVD KNVSEIIATI
   181  METLKMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IDNK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

liver: 66 nTPM
basal ganglia: 55 nTPM
kidney: 47 nTPM
choroid plexus: 38 nTPM
thymus: 36 nTPM
cerebral cortex: 29 nTPM

Single-cell type

enterocytes: 99 nCPM
hepatocytes: 64 nCPM
epicardial cells: 52 nCPM
fallopian tube ciliated cells: 47 nCPM
ependymal cells: 46 nCPM
mast cells: 43 nCPM

Immune cell

basophil: 101 nTPM
T-reg: 52 nTPM
non-classical monocyte: 48 nTPM
memory B-cell: 40 nTPM
NK-cell: 33 nTPM
gdT-cell: 31 nTPM

Brain region

basal ganglia: 24 nTPM
hypothalamus: 21 nTPM
choroid plexus: 21 nTPM
midbrain: 16 nTPM
white matter: 16 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.39
gnomAD missense Z: 0.37
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carbohydrate metabolic process

Molecular functions

ATP binding
gluconokinase activity

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Shikimate kinase/gluconokinase
Shikimate kinase
Carbohydrate kinase, thermoresistant glucokinase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IDNK as an antibody target. Whether an autoantibody or antibody against IDNK could matter depends on whether native IDNK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IDNK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IDNK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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