Seroatlas · Human Serome Atlas

RAB21

Ras-related protein Rab-21

Also known as: KIAA0118, RAB21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL25
Gene: RAB21
Ensembl: ENSG00000080371
Chromosome: 12
Canonical length: 225 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q9UL25|RAB21
     1  MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK
    61  LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM
   121  LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM
   181  IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CCSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 14 nTPM
heart muscle: 11 nTPM
blood vessel: 10 nTPM
kidney: 7.7 nTPM
spinal cord: 7.7 nTPM
bone marrow: 7.5 nTPM

Single-cell type

late spermatids: 1,003 nCPM
neutrophils: 767 nCPM
early spermatids: 645 nCPM
neutrophil progenitors: 332 nCPM
monocytes: 225 nCPM
urothelial cells: 168 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 0.7 nTPM
eosinophil: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
gdT-cell: 0.4 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 15 nTPM
spinal cord: 15 nTPM
midbrain: 15 nTPM
basal ganglia: 15 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.11
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB21 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB21 as an antibody target. Whether an autoantibody or antibody against RAB21 could matter depends on whether native RAB21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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