Seroatlas · Human Serome Atlas

GNL1

Guanine nucleotide-binding protein-like 1

Also known as: GNL1_HUMAN, HSR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P36915
Gene: GNL1
Ensembl: ENSG00000204590
Chromosome: 6
Canonical length: 607 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>P36915|GNL1
     1  MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT SDGESVTHHI
    61  RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA REQVLQPVSA ELLELDIREV
   121  YQPGSVLDFP RRPPWSYEMS KEQLMSQEER SFQDYLGKIH GAYSSEKLSY FEHNLETWRQ
   181  LWRVLEMSDI VLLITDIRHP VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH
   241  YFHQHYPQLH VVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITVG
   301  KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG PTQERYKDGV
   361  VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT YFLTPSVKLC DCPGLIFPSL
   421  LPRQLQVLAG IYPIAQIQEP YTAVGYLASR IPVQALLHLR HPEAEDPSAE HPWCAWDICE
   481  AWAEKRGYKT AKAARNDVYR AANSLLRLAV DGRLSLCFHP PGYSEQKGTW ESHPETTELV
   541  VLQGRVGPAG DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEETPTSAPG SSLAGRNPYA
   601  LLGEDEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

testis: 37 nTPM
ovary: 37 nTPM
cerebellum: 34 nTPM
cerebral cortex: 33 nTPM
basal ganglia: 33 nTPM
spinal cord: 30 nTPM

Single-cell type

late spermatids: 126 nCPM
late primary spermatocytes: 63 nCPM
early spermatids: 45 nCPM
brain inhibitory neurons: 40 nCPM
podocytes: 34 nCPM
renal collecting duct principal cells: 30 nCPM

Immune cell

memory CD8 T-cell: 1.9 nTPM
MAIT T-cell: 1.5 nTPM
memory CD4 T-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM
memory B-cell: 1.1 nTPM
T-reg: 1.1 nTPM

Brain region

white matter: 25 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 21 nTPM
thalamus: 19 nTPM
amygdala: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNL1 as an antibody target. Whether an autoantibody or antibody against GNL1 could matter depends on whether native GNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNL1 is annotated as secreted, so native GNL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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