RAB41
Ras-related protein Rab-41
Also known as: RAB41_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JT25
- Gene
- RAB41
- Ensembl
- ENSG00000147127
- Chromosome
- X
- Canonical length
- 222 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane,Cytosol
OverviewNCBI Gene
This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]
Canonical amino-acid sequenceUniProt
222 residues, UniProt reviewed canonical sequence.
>Q5JT25|RAB41
1 MSAFGHDEAW MEAGGFGLEA AERTEYQSLC KSKLLFLGEQ SVGKTSIISR FMYNSFGCAC
61 QATVGIDFLS KTMYLEDQIV QLQLWDTAGQ ERFHSLIPSY IRDSTIAVVV YDITNINSFK
121 ETDKWVEHVR AERGDDVVIM LLGNKIDLDN KRQVTAEQGE EKSRNLNVMF IETSAKTGYN
181 VKKLFRRVAS ALLSTRTSPP PKEGTVEIEL ESFEESGNRS YCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 54 nTPM
Expression across tissuesHPA
Tissue
- retina: 54 nTPM
- testis: 3.8 nTPM
- basal ganglia: 1.5 nTPM
- midbrain: 1.4 nTPM
- amygdala: 1.3 nTPM
- cerebral cortex: 1.3 nTPM
Single-cell type
- cone photoreceptor cells: 230 nCPM
- early primary spermatocytes: 32 nCPM
- undifferentiated spermatogonia: 4.1 nCPM
- goblet cells: 2.4 nCPM
- cardiomyocytes: 1.2 nCPM
- differentiating spermatogonia: 1.1 nCPM
Immune cell
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 1.6 nTPM
- medulla oblongata: 1.6 nTPM
- thalamus: 1.6 nTPM
- white matter: 1.6 nTPM
- basal ganglia: 1.5 nTPM
- hippocampal formation: 1.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.28
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
- protein localization to Golgi membrane
- retrograde transport, endosome to Golgi
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB41 as an antibody target. Whether an autoantibody or antibody against RAB41 could matter depends on whether native RAB41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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