Seroatlas · Human Serome Atlas

GTPBP6

Putative GTP-binding protein 6

Also known as: FLJ20977, GTPB6_HUMAN, PGPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43824
Gene: GTPBP6
Ensembl: ENSG00000178605
Chromosome: X
Canonical length: 516 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

516 residues, UniProt reviewed canonical sequence.

>O43824|GTPBP6
     1  MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP WGGGRGLRAD
    61  GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL VHPDVKWGPG KSQMTRAEWQ
   121  VAEATALVHT LDGWSVVQTM VVSTKTPDRK LIFGKGNFEH LTEKIRGSPD ITCVFLNVER
   181  MAAPTKKELE AAWGVEVFDR FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL
   241  YRGVGSRYIM GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV
   301  GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT IGFLSQLPHG
   361  LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL RGLQLPAPLL DSMVEVHNKV
   421  DLVPGYSPTE PNVVPVSALR GHGLQELKAE LDAAVLKATG RQILTLRVRL AGAQLSWLYK
   481  EATVQEVDVI PEDGAADVRV IISNSAYGKF RKLFPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTPBP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 67 nTPM
heart muscle: 44 nTPM
pancreas: 41 nTPM
liver: 38 nTPM
kidney: 35 nTPM
stomach: 35 nTPM

Single-cell type

esophageal basal cells: 63 nCPM
extravillous trophoblasts: 59 nCPM
thymic myoid cells: 57 nCPM
ovarian stromal cells: 54 nCPM
alveolar cells type 2: 53 nCPM
breast lactating cells: 51 nCPM

Immune cell

plasmacytoid DC: 7.4 nTPM
T-reg: 6.4 nTPM
memory CD8 T-cell: 5.6 nTPM
basophil: 5.4 nTPM
naive CD4 T-cell: 5.2 nTPM
memory B-cell: 5 nTPM

Brain region

white matter: 52 nTPM
medulla oblongata: 46 nTPM
basal ganglia: 40 nTPM
pons: 39 nTPM
midbrain: 38 nTPM
cerebral cortex: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -1.77

OntologyGO

Biological processes

mitochondrial large ribosomal subunit assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

GTP binding domain
P-loop containing nucleoside triphosphate hydrolase
50S ribosome-binding GTPase
GTPase HflX
GTPase HflX, N-terminal
HflX-type guanine nucleotide-binding (G) domain
GTP-binding protein, middle domain
GTPase HflX, N-terminal domain superfamily
GTP-binding GTPase N-terminal
GTP-binding GTPase Middle Region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTPBP6 as an antibody target. Whether an autoantibody or antibody against GTPBP6 could matter depends on whether native GTPBP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTPBP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTPBP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...