ATL2

Protein identityUniProt · HPA

UniProt accession

Q8NHH9

Gene

ATL2

Ensembl

ENSG00000119787

Chromosome

2

Canonical length

583 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q8NHH9|ATL2
     1  MAEGDEAARG QQPHQGLWRR RRTSDPSAAV NHVSSTTSLG ENYEDDDLVN SDEVMKKPCP
    61  VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN
   121  KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS
   181  QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM
   241  FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG
   301  LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI
   361  KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDTYCKSMEQ VCGGDKPYIA PSDLERKHLD
   421  LKEVAIKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA
   481  VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALIFLCTWAY VKYSGEFREI GTVIDQIAET
   541  LWEQVLKPLG DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

52 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0.01

gnomAD missense Z

0.39

DepMap mean gene effect

-0.67

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endoplasmic reticulum membrane fusion
• endoplasmic reticulum organization
• endoplasmic reticulum tubular network membrane organization
• protein homooligomerization

Molecular functions

• GTP binding
• GTPase activity
• GTPase-dependent fusogenic activity
• metal ion binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• endoplasmic reticulum tubular network membrane
• membrane

Protein domainsUniProt · Pfam · InterPro

• Guanylate-binding protein/Atlastin, C-terminal
• Guanylate-binding protein, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• GB1/RHD3-type guanine nucleotide-binding (G) domain
• Guanylate-binding protein, C-terminal domain superfamily
• Guanylate-binding protein, N-terminal domain
• Guanylate-binding protein, C-terminal domain

KeywordsUniProt

• Coiled coil
• Endoplasmic reticulum
• GTP-binding
• Hydrolase
• Magnesium
• Membrane
• Metal-binding
• Methylation
• Nucleotide-binding
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ATL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• REEP5
• RTN3
• ZFYVE27
• ATL3
• COPE
• COPG1