Seroatlas · Human Serome Atlas

NUBP1

Cytosolic Fe-S cluster assembly factor NUBP1

Also known as: CIAO5, NBP1, NBP35, NUBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53384
Gene
NUBP1
Ensembl
ENSG00000103274
Chromosome
16
Canonical length
320 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Centrosome,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>P53384|NUBP1
     1  MEEVPHDCPG ADSAQAGRGA SCQGCPNQRL CASGAGATPD TAIEEIKEKM KTVKHKILVL
    61  SGKGGVGKST FSAHLAHGLA EDENTQIALL DIDICGPSIP KIMGLEGEQV HQSGSGWSPV
   121  YVEDNLGVMS VGFLLSSPDD AVIWRGPKKN GMIKQFLRDV DWGEVDYLIV DTPPGTSDEH
   181  LSVVRYLATA HIDGAVIITT PQEVSLQDVR KEINFCRKVK LPIIGVVENM SGFICPKCKK
   241  ESQIFPPTTG GAELMCQDLE VPLLGRVPLD PLIGKNCDKG QSFFIDAPDS PATLAYRSII
   301  QRIQEFCNLH QSKEENLISS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 45 nTPM
  • adrenal gland: 38 nTPM
  • skeletal muscle: 36 nTPM
  • tonsil: 35 nTPM
  • tongue: 32 nTPM
  • pancreas: 31 nTPM

Single-cell type

  • cdc: 99 nCPM
  • granulosa cells: 82 nCPM
  • syncytiotrophoblasts: 81 nCPM
  • oocytes: 74 nCPM
  • cytotrophoblasts: 64 nCPM
  • hofbauer cells: 62 nCPM

Immune cell

  • myeloid DC: 90 nTPM
  • intermediate monocyte: 88 nTPM
  • classical monocyte: 83 nTPM
  • memory B-cell: 76 nTPM
  • naive B-cell: 70 nTPM
  • non-classical monocyte: 67 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • white matter: 14 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 13 nTPM
  • medulla oblongata: 13 nTPM
  • cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0
gnomAD missense Z
-0.94
DepMap mean gene effect
-1.16
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUBP1 as an antibody target. Whether an autoantibody or antibody against NUBP1 could matter depends on whether native NUBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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