Seroatlas · Human Serome Atlas

MYO1D

Unconventional myosin-Id

Also known as: KIAA0727, MYO1D_HUMAN, myr4, PPP1R108

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94832
Gene: MYO1D
Ensembl: ENSG00000176658
Chromosome: 17
Canonical length: 1006 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables protein domain specific binding activity. Predicted to be involved in several processes, including actin filament organization; actin filament-based movement; and early endosome to recycling endosome transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1006 residues, UniProt reviewed canonical sequence.

>O94832|MYO1D
     1  MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN PYKLLNIYGR
    61  DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIVI SGESGAGKTE ASKYIMQYIA
   121  AITNPSQRAE VERVKNMLLK SNCVLEAFGN AKTNRNDNSS RFGKYMDINF DFKGDPIGGH
   181  INNYLLEKSR VIVQQPGERS FHSFYQLLQG GSEQMLRSLH LQKSLSSYNY IHVGAQLKSS
   241  INDAAEFRVV ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFVVDGDTPL IENGKVVSII
   301  AELLSTKTDM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER LFCWIVTRIN
   361  DIIEVKNYDT TIHGKNTVIG VLDIYGFEIF DNNSFEQFCI NYCNEKLQQL FIQLVLKQEQ
   421  EEYQREGIPW KHIDYFNNQI IVDLVEQQHK GIIAILDDAC MNVGKVTDEM FLEALNSKLG
   481  KHAHFSSRKL CASDKILEFD RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN
   541  PVLKNMWPEG KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
   601  FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH DLPSDKEAVK
   661  KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLIR IVLFLQKVWR GTLARMRYKR
   721  TKAALTIIRY YRRYKVKSYI HEVARRFHGV KTMRDYGKHV KWPSPPKVLR RFEEALQTIF
   781  NRWRASQLIK SIPASDLPQV RAKVAAVEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT
   841  FVPVANELKR KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
   901  LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV NHFKSEKRHL
   961  QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI LSVPGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 224 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 224 nTPM
colon: 104 nTPM
rectum: 86 nTPM
duodenum: 80 nTPM
small intestine: 79 nTPM
skin: 39 nTPM

Single-cell type

colonocytes: 1,138 nCPM
podocytes: 1,065 nCPM
goblet cells: 950 nCPM
oligodendrocytes: 718 nCPM
enteric transient amplifying cells: 593 nCPM
alveolar cells type 1: 585 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

white matter: 110 nTPM
medulla oblongata: 59 nTPM
basal ganglia: 58 nTPM
cerebellum: 53 nTPM
midbrain: 49 nTPM
thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin filament organization
actin filament-based movement
early endosome to recycling endosome transport
endocytosis
protein transport
cellular localization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYO1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CALM3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYO1D as an antibody target. Whether an autoantibody or antibody against MYO1D could matter depends on whether native MYO1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYO1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYO1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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