Seroatlas · Human Serome Atlas

THNSL1

Threonine synthase-like 1

Also known as: FLJ22002, THNS1_HUMAN, TSH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYQ7
Gene
THNSL1
Ensembl
ENSG00000185875
Chromosome
10
Canonical length
743 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Mitochondria,Cytosol

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

743 residues, UniProt reviewed canonical sequence.

>Q8IYQ7|THNSL1
     1  MLHFNRCHHL KKITQKCFSS IHVKTDKHAQ RFLSRTFALA ELRKSWYSTH SLVGDKNIIL
    61  MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS EKLQDVGNEQ FLEEEGKAVL
   121  NFSASGSVIS LTGSNPMHDA SMWHLKKNGI IVYLDVPLLD LICRLKLMKT DRIVGQNSGT
   181  SMKDLLKFRR QYYKKWYDAR VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPE
   241  DCEQKVSAKF FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYVE RAQILLERCI
   301  HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF KDLSLQLMPH
   361  IFAHCIPPSC NYMILVATSG DTGSAVLNGF SRLNKNDKQR IAVVAFFPEN GVSDFQKAQI
   421  IGSQRENGWA VGVESDFDFC QTAIKRIFND SDFTGFLTVE YGTILSSANS INWGRLLPQV
   481  VYHASAYLDL VSQGFISFGS PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNHVL
   541  TDFIKTGHYD LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNRLESQHHF
   601  QIEKALVEKL QQDFVADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA DRVQDKTCPV
   661  IISSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA LPPLHEALLE RTKQQEKMEY
   721  QVCAADMNVL KSHVEQLVQN QFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THNSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • liver: 20 nTPM
  • kidney: 9.1 nTPM
  • thyroid gland: 7.8 nTPM
  • ovary: 6.8 nTPM
  • adrenal gland: 5.7 nTPM
  • testis: 5.5 nTPM

Single-cell type

  • other brain neurons: 9.7 nCPM
  • brain inhibitory neurons: 9 nCPM
  • oligodendrocytes: 8.2 nCPM
  • brain excitatory neurons: 7.7 nCPM
  • microglia: 7.6 nCPM
  • ependymal cells: 6.5 nCPM

Immune cell

  • NK-cell: 11 nTPM
  • naive CD4 T-cell: 9.5 nTPM
  • naive CD8 T-cell: 6.3 nTPM
  • MAIT T-cell: 5.1 nTPM
  • memory B-cell: 5 nTPM
  • memory CD4 T-cell: 4.1 nTPM

Brain region

  • hypothalamus: 9.1 nTPM
  • cerebral cortex: 8.9 nTPM
  • white matter: 8.9 nTPM
  • basal ganglia: 8.8 nTPM
  • pons: 8.8 nTPM
  • spinal cord: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THNSL1 as an antibody target. Whether an autoantibody or antibody against THNSL1 could matter depends on whether native THNSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THNSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THNSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THNSL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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