Seroatlas · Human Serome Atlas

SULT1B1

Sulfotransferase 1B1

Also known as: ST1B1_HUMAN, ST1B2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43704
Gene: SULT1B1
Ensembl: ENSG00000173597
Chromosome: 4
Canonical length: 296 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>O43704|SULT1B1
     1  MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG TTWVSEIIDM
    61  ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN PSPRIVKTHL PTDLLPKSFW
   121  ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW
   181  WKKKEEHPIL FLYYEDMKEN PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN
   241  YTHLPTTVMD HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

duodenum: 93 nTPM
small intestine: 89 nTPM
colon: 65 nTPM
rectum: 58 nTPM
stomach: 42 nTPM
liver: 22 nTPM

Single-cell type

neutrophils: 509 nCPM
colonocytes: 285 nCPM
enterocytes: 258 nCPM
foveolar cells: 163 nCPM
parietal cells: 113 nCPM
enteric transient amplifying cells: 94 nCPM

Immune cell

neutrophil: 32 nTPM
basophil: 11 nTPM
naive CD4 T-cell: 4.9 nTPM
classical monocyte: 4.8 nTPM
non-classical monocyte: 3.4 nTPM
NK-cell: 2.9 nTPM

Brain region

cerebellum: 38 nTPM
cerebral cortex: 35 nTPM
white matter: 33 nTPM
choroid plexus: 30 nTPM
basal ganglia: 28 nTPM
hippocampal formation: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1B1 as an antibody target. Whether an autoantibody or antibody against SULT1B1 could matter depends on whether native SULT1B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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