Seroatlas · Human Serome Atlas

RAB26

Ras-related protein Rab-26

Also known as: RAB26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULW5
Gene
RAB26
Ensembl
ENSG00000167964
Chromosome
16
Canonical length
256 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cell Junctions,Centrosome,Cytosol

OverviewNCBI Gene

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q9ULW5|RAB26
     1  MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR PSLGGGVDFY
    61  DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID FRNKVLDVDG VKVKLQMWDT
   121  AGQERFRSVT HAYYRDAHAL LLLYDVTNKA SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD
   181  SAHERVVKRE DGEKLAKEYG LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL
   241  HDYVKREGRG ASCCRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 116 nTPM
  • hippocampal formation: 68 nTPM
  • basal ganglia: 64 nTPM
  • cerebral cortex: 57 nTPM
  • liver: 51 nTPM
  • amygdala: 50 nTPM

Single-cell type

  • paneth cells: 248 nCPM
  • colonocytes: 197 nCPM
  • goblet cells: 170 nCPM
  • enterocytes: 127 nCPM
  • neuroendocrine cells: 125 nCPM
  • breast myoepithelial cells: 123 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 44 nTPM
  • cerebral cortex: 42 nTPM
  • cerebellum: 38 nTPM
  • basal ganglia: 30 nTPM
  • white matter: 25 nTPM
  • amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
-0.81
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB26 as an antibody target. Whether an autoantibody or antibody against RAB26 could matter depends on whether native RAB26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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