SULT2A1

Protein identityUniProt · HPA

UniProt accession

Q06520

Gene

SULT2A1

Ensembl

ENSG00000105398

Chromosome

19

Canonical length

285 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q06520|SULT2A1
     1  MSDDFLWFEG IAFPTMGFRS ETLRKVRDEF VIRDEDVIIL TYPKSGTNWL AEILCLMHSK
    61  GDAKWIQSVP IWERSPWVES EIGYTALSET ESPRLFSSHL PIQLFPKSFF SSKAKVIYLM
   121  RNPRDVLVSG YFFWKNMKFI KKPKSWEEYF EWFCQGTVLY GSWFDHIHGW MPMREEKNFL
   181  LLSYEELKQD TGRTIEKICQ FLGKTLEPEE LNLILKNSSF QSMKENKMSN YSLLSVDYVV
   241  DKAQLLRKGV SGDWKNHFTV AQAEDFDKLF QEKMADLPRE LFPWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

1,005 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0

gnomAD missense Z

0.45

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 3'-phosphoadenosine 5'-phosphosulfate metabolic process
• bile acid catabolic process
• bile acid metabolic process
• cholesterol metabolic process
• ethanol catabolic process
• lipid catabolic process
• sensory perception of itch
• steroid metabolic process
• sulfation
• thyroid hormone metabolic process
• xenobiotic metabolic process

Molecular functions

• 3'-phosphoadenosine 5'-phosphosulfate binding
• alcohol sulfotransferase activity
• bile-salt sulfotransferase activity
• steroid sulfotransferase activity
• sulfotransferase activity

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Sulfotransferase domain
• P-loop containing nucleoside triphosphate hydrolase
• Sulfotransferase domain

KeywordsUniProt

• Bile acid catabolism
• Cytoplasm
• Lipid degradation
• Lipid metabolism
• Phosphoprotein
• Steroid metabolism
• Transferase

InteractionsUniProt · HPA

Protein binding partners of SULT2A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STAT3