Seroatlas · Human Serome Atlas

DDX17

Probable ATP-dependent RNA helicase DDX17

Also known as: DDX17_HUMAN, P72

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92841
Gene: DDX17
Ensembl: ENSG00000100201
Chromosome: 22
Canonical length: 729 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q92841|DDX17
     1  MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ
    61  ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK
   121  KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ
   181  YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE
   241  RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
   301  TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP
   361  KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK
   421  TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR
   481  GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA
   541  NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
   601  SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY
   661  GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP
   721  PPPPPPSRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 317 nTPM

Expression across tissuesHPA

Tissue

retina: 317 nTPM
pituitary gland: 300 nTPM
ovary: 293 nTPM
thyroid gland: 291 nTPM
spleen: 284 nTPM
cervix: 254 nTPM

Single-cell type

pituitary stem cells: 916 nCPM
neutrophils: 911 nCPM
podocytes: 885 nCPM
pituicytes/fscs: 881 nCPM
lactotrophs: 814 nCPM
thyrotrophs: 790 nCPM

Immune cell

neutrophil: 17 nTPM
plasmacytoid DC: 11 nTPM
eosinophil: 9.6 nTPM
T-reg: 9.2 nTPM
memory B-cell: 9 nTPM
MAIT T-cell: 8.9 nTPM

Brain region

white matter: 246 nTPM
choroid plexus: 213 nTPM
basal ganglia: 176 nTPM
medulla oblongata: 169 nTPM
hypothalamus: 161 nTPM
cerebral cortex: 161 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX17.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 38 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 3.87
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX17 as an antibody target. Whether an autoantibody or antibody against DDX17 could matter depends on whether native DDX17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...