Seroatlas · Human Serome Atlas

MPP2

MAGUK p55 subfamily member 2

Also known as: DKFZp761D0712, DLG2, MPP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14168
Gene
MPP2
Ensembl
ENSG00000108852
Chromosome
17
Canonical length
576 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q14168|MPP2
     1  MPVAATNSET AMQQVLDNLG SLPSATGAAE LDLIFLRGIM ESPIVRSLAK VIMVLWFMQQ
    61  NVFVPMKYML KYFGAHERLE ETKLEAVRDN NLELVQEILR DLAHVAEQSS TAAELAHILQ
   121  EPHFQSLLET HDSVASKTYE TPPPSPGLDP TFSNQPVPPD AVRMVGIRKT AGEHLGVTFR
   181  VEGGELVIAR ILHGGMVAQQ GLLHVGDIIK EVNGQPVGSD PRALQELLRN ASGSVILKIL
   241  PSYQEPHLPR QVFVKCHFDY DPARDSLIPC KEAGLRFNAG DLLQIVNQDD ANWWQACHVE
   301  GGSAGLIPSQ LLEEKRKAFV KRDLELTPNS GTLCGSLSGK KKKRMMYLTT KNAEFDRHEL
   361  LIYEEVARMP PFRRKTLVLI GAQGVGRRSL KNKLIMWDPD RYGTTVPYTS RRPKDSEREG
   421  QGYSFVSRGE MEADVRAGRY LEHGEYEGNL YGTRIDSIRG VVAAGKVCVL DVNPQAVKVL
   481  RTAEFVPYVV FIEAPDFETL RAMNRAALES GISTKQLTEA DLRRTVEESS RIQRGYGHYF
   541  DLCLVNSNLE RTFRELQTAM EKLRTEPQWV PVSWVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 33 nTPM
  • cerebellum: 30 nTPM
  • epididymis: 25 nTPM
  • cerebral cortex: 23 nTPM
  • hippocampal formation: 21 nTPM
  • hypothalamus: 21 nTPM

Single-cell type

  • retinal bipolar cells: 108 nCPM
  • early spermatids: 100 nCPM
  • oligodendrocytes: 63 nCPM
  • choroid plexus epithelial cells: 50 nCPM
  • corticotrophs: 46 nCPM
  • early primary spermatocytes: 45 nCPM

Immune cell

  • naive CD8 T-cell: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • white matter: 90 nTPM
  • medulla oblongata: 70 nTPM
  • thalamus: 65 nTPM
  • midbrain: 64 nTPM
  • cerebral cortex: 63 nTPM
  • pons: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.51
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPP2 as an antibody target. Whether an autoantibody or antibody against MPP2 could matter depends on whether native MPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MPP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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