Seroatlas · Human Serome Atlas

RHEBL1

GTPase RhebL1

Also known as: FLJ25797, MGC34869, REBL1_HUMAN, RHEB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAI7
Gene: RHEBL1
Ensembl: ENSG00000167550
Chromosome: 12
Canonical length: 183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Centrosome

OverviewNCBI Gene

Enables GTP binding activity. Involved in TOR signaling and positive regulation of NF-kappaB transcription factor activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q8TAI7|RHEBL1
     1  MPLVRYRKVV ILGYRCVGKT SLAHQFVEGE FSEGYDPTVE NTYSKIVTLG KDEFHLHLVD
    61  TAGQDEYSIL PYSFIIGVHG YVLVYSVTSL HSFQVIESLY QKLHEGHGKT RVPVVLVGNK
   121  ADLSPEREVQ AVEGKKLAES WGATFMESSA RENQLTQGIF TKVIQEIARV ENSYGQERRC
   181  HLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHEBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.2 nTPM
lymph node: 3.4 nTPM
skin: 2.5 nTPM
fallopian tube: 2.4 nTPM
spleen: 2.4 nTPM
bone marrow: 1.9 nTPM

Single-cell type

granulosa cells: 40 nCPM
oocytes: 28 nCPM
respiratory ciliated cells: 21 nCPM
epididymal efferent duct ciliated cells: 17 nCPM
nk-cells: 17 nCPM
fallopian tube ciliated cells: 15 nCPM

Immune cell

basophil: 16 nTPM
MAIT T-cell: 11 nTPM
gdT-cell: 7.6 nTPM
T-reg: 6.8 nTPM
memory CD8 T-cell: 4.1 nTPM
naive CD8 T-cell: 3.8 nTPM

Brain region

cerebral cortex: 2.1 nTPM
white matter: 2 nTPM
medulla oblongata: 1.8 nTPM
basal ganglia: 1.5 nTPM
hypothalamus: 1.4 nTPM
pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHEBL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHEBL1 as an antibody target. Whether an autoantibody or antibody against RHEBL1 could matter depends on whether native RHEBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHEBL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHEBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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