Seroatlas · Human Serome Atlas

DDX43

Probable ATP-dependent RNA helicase DDX43

Also known as: CT13, DDX43_HUMAN, DKFZp434H2114, HAGE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXZ2
Gene: DDX43
Ensembl: ENSG00000080007
Chromosome: 6
Canonical length: 648 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q9NXZ2|DDX43
     1  MSHHGGAPKA STWVVASRRS STVSRAPERR PAEELNRTGP EGYSVGRGGR WRGTSRPPEA
    61  VAAGHEELPL CFALKSHFVG AVIGRGGSKI KNIQSTTNTT IQIIQEQPES LVKIFGSKAM
   121  QTKAKAVIDN FVKKLEENYN SECGIDTAFQ PSVGKDGSTD NNVVAGDRPL IDWDQIREEG
   181  LKWQKTKWAD LPPIKKNFYK ESTATSAMSK VEADSWRKEN FNITWDDLKD GEKRPIPNPT
   241  CTFDDAFQCY PEVMENIKKA GFQKPTPIQS QAWPIVLQGI DLIGVAQTGT GKTLCYLMPG
   301  FIHLVLQPSL KGQRNRPGML VLTPTRELAL QVEGECCKYS YKGLRSVCVY GGGNRDEQIE
   361  ELKKGVDIII ATPGRLNDLQ MSNFVNLKNI TYLVLDEADK MLDMGFEPQI MKILLDVRPD
   421  RQTVMTSATW PHSVHRLAQS YLKEPMIVYV GTLDLVAVSS VKQNIIVTTE EEKWSHMQTF
   481  LQSMSSTDKV IVFVSRKAVA DHLSSDLILG NISVESLHGD REQRDREKAL ENFKTGKVRI
   541  LIATDLASRG LDVHDVTHVY NFDFPRNIEE YVHRIGRTGR AGRTGVSITT LTRNDWRVAS
   601  ELINILERAN QSIPEELVSM AERFKAHQQK REMERKMERP QGRPKKFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
placenta: 4.6 nTPM
salivary gland: 1.7 nTPM
seminal vesicle: 1.7 nTPM
stomach: 1.6 nTPM
blood vessel: 1.3 nTPM

Single-cell type

oocytes: 97 nCPM
undifferentiated spermatogonia: 81 nCPM
late primary spermatocytes: 62 nCPM
early primary spermatocytes: 50 nCPM
differentiating spermatogonia: 47 nCPM
cytotrophoblasts: 29 nCPM

Immune cell

gdT-cell: 1 nTPM
naive B-cell: 1 nTPM
eosinophil: 0.9 nTPM
memory B-cell: 0.9 nTPM
memory CD8 T-cell: 0.9 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

white matter: 1.8 nTPM
medulla oblongata: 1.7 nTPM
pons: 1.6 nTPM
cerebral cortex: 1.1 nTPM
thalamus: 1.1 nTPM
hypothalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX43 as an antibody target. Whether an autoantibody or antibody against DDX43 could matter depends on whether native DDX43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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