RAB33A
Ras-related protein Rab-33A
Also known as: RabS10, RB33A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q14088
- Gene
- RAB33A
- Ensembl
- ENSG00000134594
- Chromosome
- X
- Canonical length
- 237 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
237 residues, UniProt reviewed canonical sequence.
>Q14088|RAB33A
1 MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT CLTFRFCGGT
61 FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK SMVEHYYRNV HAVVFVYDVT
121 KMTSFTNLKM WIQECNGHAV PPLVPKVLVG NKCDLREQIQ VPSNLALKFA DAHNMLLFET
181 SAKDPKESQN VESIFMCLAC RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB33A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 44 nTPM
- cerebellum: 29 nTPM
- hippocampal formation: 29 nTPM
- cerebral cortex: 25 nTPM
- midbrain: 23 nTPM
- basal ganglia: 22 nTPM
Single-cell type
- megakaryocytes: 87 nCPM
- oligodendrocytes: 34 nCPM
- platelets: 21 nCPM
- mast cells: 16 nCPM
- retinal ganglion cells: 16 nCPM
- hepatic stellate cells: 13 nCPM
Immune cell
- eosinophil: 88 nTPM
- T-reg: 73 nTPM
- naive CD8 T-cell: 40 nTPM
- basophil: 40 nTPM
- memory CD8 T-cell: 33 nTPM
- gdT-cell: 32 nTPM
Brain region
- white matter: 54 nTPM
- pons: 31 nTPM
- medulla oblongata: 30 nTPM
- cerebral cortex: 30 nTPM
- spinal cord: 27 nTPM
- cerebellum: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.53
- gnomAD pLI
- 0.82
- gnomAD missense Z
- 1.93
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB33A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB33A as an antibody target. Whether an autoantibody or antibody against RAB33A could matter depends on whether native RAB33A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB33A is annotated at the cell surface, where native RAB33A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RAB33A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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