Seroatlas · Human Serome Atlas

RAB11A

Ras-related protein Rab-11A

Also known as: RB11A_HUMAN, YL8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62491
Gene
RAB11A
Ensembl
ENSG00000103769
Chromosome
15
Canonical length
216 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles,Primary cilium,Centriolar satellite,Basal body,Cytosol,Equatorial segment,Mid piece,Principal piece

OverviewNCBI Gene

The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>P62491|RAB11A
     1  MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI
    61  KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM
   121  LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ
   181  MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
451 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 451 nTPM
  • skin: 271 nTPM
  • urinary bladder: 252 nTPM
  • tonsil: 230 nTPM
  • vagina: 218 nTPM
  • adrenal gland: 211 nTPM

Single-cell type

  • esophageal apical cells: 4,604 nCPM
  • epicardial cells: 2,206 nCPM
  • platelets: 1,543 nCPM
  • syncytiotrophoblasts: 1,452 nCPM
  • esophageal suprabasal cells: 981 nCPM
  • cdc: 942 nCPM

Immune cell

  • total PBMC: 341 nTPM
  • eosinophil: 236 nTPM
  • neutrophil: 234 nTPM
  • basophil: 184 nTPM
  • non-classical monocyte: 155 nTPM
  • classical monocyte: 155 nTPM

Brain region

  • pons: 160 nTPM
  • hypothalamus: 151 nTPM
  • spinal cord: 128 nTPM
  • medulla oblongata: 128 nTPM
  • white matter: 127 nTPM
  • basal ganglia: 124 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB11A.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
0.99
gnomAD missense Z
3.09
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11A as an antibody target. Whether an autoantibody or antibody against RAB11A could matter depends on whether native RAB11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11A is annotated at the cell surface, where native RAB11A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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