MYH10

Protein identityUniProt · HPA

UniProt accession

P35580

Gene

MYH10

Ensembl

ENSG00000133026

Chromosome

17

Canonical length

1976 aa

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Actin filaments,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

1976 residues, UniProt reviewed canonical sequence.

>P35580|MYH10
     1  MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV
    61  ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
   121  FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
   181  GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS
   241  RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
   301  LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS
   361  FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA
   421  VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN
   481  EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW
   541  FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
   601  DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES
   661  LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV
   721  FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE
   781  ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK
   841  VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
   901  ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD
   961  EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE
  1021  KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE
  1081  LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ
  1141  KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR
  1201  HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ
  1261  VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT
  1321  QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV
  1381  DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR
  1441  QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE
  1501  EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED
  1561  AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK
  1621  KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK
  1681  KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ
  1741  LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK
  1801  LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED
  1861  ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE
  1921  VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYH10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

254 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYH10.

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 367 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inborn genetic diseases
• 7 conditions
• 6 conditions
• Complex neurodevelopmental disorders
• See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.17

gnomAD pLI

1

gnomAD missense Z

5.01

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament-based movement
• actomyosin structure organization
• adult heart development
• aorta development
• axon guidance
• cardiac muscle cell proliferation
• cardiac myofibril assembly
• cardiac septum development
• cell adhesion
• cerebellar Purkinje cell layer development
• coronary vasculature development
• exocytosis
• fourth ventricle development
• in utero embryonic development
• lateral ventricle development
• mitotic cytokinesis
• neuromuscular process controlling balance
• neuron migration
• nuclear migration
• plasma membrane repair
• positive regulation of protein secretion
• postsynaptic actin cytoskeleton organization
• regulation of cell shape
• retina development in camera-type eye
• substrate-dependent cell migration, cell extension
• symbiont entry into host cell
• third ventricle development
• ventricular cardiac muscle cell development

Molecular functions

• actin binding
• actin filament binding
• ADP binding
• ATP binding
• calmodulin binding
• microfilament motor activity
• mRNA 5'-UTR binding
• RNA stem-loop binding
• virus receptor activity

Cellular components

• actomyosin
• brush border
• cell cortex
• cell surface
• cleavage furrow
• cytoplasm
• cytoplasmic side of plasma membrane
• cytosol
• dendritic spine
• extracellular exosome
• glutamatergic synapse
• growth cone
• lamellipodium
• midbody
• myosin complex
• myosin filament
• myosin II complex
• myosin II filament
• neuromuscular junction
• neuronal cell body
• nucleus
• postsynaptic actin cytoskeleton
• sarcoplasm
• spindle
• stress fiber

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• Myosin head, motor domain-like
• Myosin tail
• Myosin, SH3 domain
• Myosin S1 fragment, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin motor domain superfamily
• Myosin head (motor domain)
• IQ calmodulin-binding motif
• Myosin tail
• Myosin N-terminal SH3-like domain

KeywordsUniProt

• Acetylation
• Actin-binding
• ATP-binding
• Calmodulin-binding
• Cell adhesion
• Cell membrane
• Cell projection
• Cell shape
• Coiled coil
• Host cell receptor for virus entry
• Membrane
• Methylation
• Motor protein
• Myosin
• Nucleotide-binding
• Phosphoprotein
• Receptor

InteractionsUniProt · HPA

Protein binding partners of MYH10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CFAP95
• ECPAS
• KIF26B
• LARP6
• MCC
• PLEKHG6
• CLN3
• MYL6
• MYL9