DNAH12

Protein identityUniProt · HPA

UniProt accession

Q6ZR08

Gene

DNAH12

Ensembl

ENSG00000174844

Chromosome

3

Canonical length

3092 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Centrosome,Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in axoneme and microtubule. Predicted to be part of axonemal dynein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3092 residues, UniProt reviewed canonical sequence.

>Q6ZR08|DNAH12
     1  MSDANKAAIA AEKEALNLKL PPIVHLPENI GVDTPTQSKL LKYRRSKEQQ QKINQLVIDG
    61  AKRNLDRTLG KRTPLLPPPD YPQTMTSEMK KKGFNYIYMK QCVESSPLVP IQQEWLDHML
   121  RLIPESLKEG KEREELLESL INEVSSDFEN SMKRYLVQSV LVKPPVKSLE DEGGPLPESP
   181  VGLDYSNPWH SSYVQARNQI FSNLHIIHPT MKMLLDLGYT TFADTVLLDF TGIRAKGPID
   241  CESLKTDLSI QTRNAEEKIM NTWYPKVINL FTKKEALEGV KPEKLDAFYS CVSTLMSNQL
   301  KDLLRRTVEG FVKLFDPKDQ QRLPIFKIEL TFDDDKMEFY PTFQDLEDNV LSLVERIAEA
   361  LQNVQTIPSW LSGTSTPVNL DTELPEHVLH WAVDTLKAAV HRNLEGARKH YETYVEKYNW
   421  LLDGTAVENI ETFQTEDHTF DEYTEFIEKF LSLASEIMLL PQWIHYTMVR LDCEDLKTGL
   481  TNKAKAFANI LLNDIASKYR KENECICSEF EAIKEHALKV PETTEEMMDL ISYVEKARTV
   541  GIEELILRIQ ESKRQMSYFL DVFLFPQEDL ALNATVLMWP RKINPIFDEN DELIENAKHK
   601  KENELMAKRE KLILEIEKES RRMEEFTEFA ELERMQQYVT DVRQLQKRIQ ESEEAVQFIN
   661  KEEELFKWEL TKYPELDKLK VNIEPYQKFF NFVLKWQRSE KRWMDGGFLD LNGESMEADV
   721  EEFSREIFKT LKFFQTKLKK ELQEKRKAAR KRSLEEEKIE EEPKDNATIT MCRMRARHWK
   781  QISEIVGYDL TPDSGTTLRK VLKLNLTPYL EQFEVISAGA SKEFSLEKAM NTMIGTWEDI
   841  AFHISLYRDT GVCILSSVDE IQAILDDQII KTQTMRGSPF IKPFEHEIKA WEDRLIRIQE
   901  TIDEWLKVQA QWLYLEPIFC SEDIMQQMPE EGRQFQTVDR HWRDIMKFCA KDPKVLAATS
   961  LTGLLEKLQN CNELLEKIMK GLNAYLEKKR LFFPRFFFLS NDEMLEILSE TKDPLRVQPH
  1021  LKKCFEGIAK LEFLPNLDIK AMYSSEGERV ELIALISTSA ARGAVEKWLI QVEDLMLRSV
  1081  HDVIAAARLA YPESARRDWV REWPGQVVLC ISQMFWTSET QEVISGGTEG LKKYYKELQN
  1141  QLNEIVELVR GKLSKQTRTT LGALVTIDVH ARDVVMDMIK MGVSHDTDFL WLAQLRYYWE
  1201  NENARVRIIN CNVKYAYEYL GNSPRLVITP LTDRCYRTLI GAFYLNLGGA PEGPAGTGKT
  1261  ETTKDLAKAL AVQCVVFNCS DGLDYLAMGK FFKGLASSGA WACFDEFNRI ELEVLSVVAQ
  1321  QILCIQRAIQ QKLVVFVFEG TELKLNPNCF VAITMNPGYA GRSELPDNLK VLFRTVAMMV
  1381  PNYALIAEIS LYSYGFLNAR PLSVKIVMTY RLCSEQLSSQ FHYDYGMRAV KAVLVAAGNL
  1441  KLKYPNENED ILLLRSIKDV NEPKFLSHDI PLFNGITSDL FPGIKLPEAD YHEFLECAHE
  1501  ACNVHNLQPV KFFLEKIIQT YEMMIVRHGF MLVGEPFAAK TKVLHVLADT LTLMNEHGYG
  1561  EEEKVIYRTV NPKSITMGQL FGQFDPVSHE WTDGIVANTF REFALSETPD RKWVVFDGPI
  1621  DTLWIESMNT VLDDNKKLCL MSGEIIQMSP QMSLIFETMD LSQASPATVS RCGMIYLEPS
  1681  QLGWEPLVSS WLNSLKGPLC EPEYQALLRG LFAWLIPPSL NQRVELFQLN YLYTTIVSKI
  1741  LKILITFRIS NYFKYVPLKT QCTFIKFFLH QQACFIFSLI WSIGGSCDTD GRRVFDTFIR
  1801  LIILGKDDEN PVPDSVGKWE CPFDEKGLVY DYMYELKNKG RWVHWNELIK NTNLGDKQIK
  1861  IQDIIVPTMD TIRYTFLMDL SITYAKPLLF VGPTGTGKSV YVKDKLMNHL EKDQYFPFYI
  1921  NLSARTSANQ VQNIIMARLD KRRKGVFGPP MGKKCIIFID DMNMPALEKY GAQPPIELLR
  1981  QFFDCGHWYD LKDTSKITLV DIELIAAMGP PGGGRNPVTP RCIRHFNICS INSFSDETMV
  2041  RIFSSIVAFY LRTHEFPPEY FVIGNQIVNG TMEIYKQSVE NLLPTPTKSH YTFNLRDFSR
  2101  VIRGCLLIER DAVANKHTMI RLFVHEVLRV FYDRLINDDD RRWLFQLTKT VIKDHFKESF
  2161  HSIFSHLRKQ NAPVTEEDLR NLMFGDYMNP DLEGDDRVYI EIPNIHHFSD VVDQCLDEYN
  2221  QTHKTRMNLV IFRYVLEHLS RICRVLKQSG GNALLVGLGG SGRQSLTRLA TSMAKMHIFQ
  2281  PEISKSYGMN EWREDMKSFI AVPVTNRIVD NKSKILEKRL RYLNDHFTYN LYCNICRSLF
  2341  EKDKLLFSFL LCANLLLARK EIEYQELMFL LTGGVSLKSA EKNPDPTWLQ DKSWEEICRA
  2401  SEFPAFRGLR QHFCEHIYEW REIYDSKEPH NAKFPAPMDK NLNELQKIII LRCLRPDKIT
  2461  PAITNYVTDK LGKKFVEPPP FDLTKSYLDS NCTIPLIFVL SPGADPMASL LKFANDKSMS
  2521  GNKFQAISLG QGQGPIAAKM IKAAIEEGTW VCLQNCHLAV SWMPMLEKIC EDFTSETCNS
  2581  SFRLWLTSYP SSKFPVTILQ NGVKMTNEPP TGLRLNLLQS YLTDPVSDPE FFKGCRGKEL
  2641  AWEKLLFGVC FFHALVQERK KFGPLGWNIP YGFNESDLRI SIRQLQLFIN EYDTIPFEAI
  2701  SYLTGECNYG GRVTDDWDRR LLLTMLADFY NLYIVENPHY KFSPSGNYFA PPKGTYEDYI
  2761  EFIKKLPFTQ HPEIFGLHEN VDISKDLQQT KTLFESLLLT QGGSKQTGAS GSTDQILLEI
  2821  TKDILNKLPS DFDIEMALRK YPVRYEESMN TVLVQEMERF NNLIITIRNT LRDLEKAIKG
  2881  VVVMDSALEA LSGSLLVGKV PEIWAKRSYP SLKPLGSYIT DFLARLNFLQ DWYNSGKPCV
  2941  FWLSGFFFTQ AFLTGAMQNY ARKYTTPIDL LGYEFEVIPS DTSDTSPEDG VYIHGLYLDG
  3001  ARWDRESGLL AEQYPKLLFD LMPIIWIKPT QKSRIIKSDA YVCPLYKTSE RKGTLSTTGH
  3061  STNFVIAMLL KTDQPTRHWI KRGVALLCQL DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAH12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

9.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAH12.

Disease | AllUniProt

Conditions DNAH12 is implicated in, by any mechanism.

• Spermatogenic failure 100 (SPGF100) MIM:621209

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 384 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spermatogenic failure 100

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

0.62

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonemal dynein complex assembly
• sperm axoneme assembly
• spermatid development

Molecular functions

• ATP binding
• dynein intermediate chain binding
• dynein light intermediate chain binding
• minus-end-directed microtubule motor activity

Cellular components

• axonemal dynein complex
• microtubule
• sperm flagellum

Protein domainsUniProt · Pfam · InterPro

• AAA+ ATPase domain
• Dynein heavy chain, D6 P-loop domain
• Dynein heavy chain, linker
• Dynein heavy chain, AAA module D4
• Dynein heavy chain
• P-loop containing nucleoside triphosphate hydrolase
• Dynein heavy chain, hydrolytic ATP-binding dynein motor region
• Dynein heavy chain, C-terminal domain
• Dynein heavy chain, AAA 5 extension domain
• Dynein heavy chain 3, AAA+ lid domain
• Dynein heavy chain, AAA lid domain
• Dynein heavy chain, AAA lid domain superfamily
• Dynein heavy chain, domain 2, N-terminal
• Dynein heavy chain, linker, subdomain 3
• Dynein heavy chain, AAA1 domain, small subdomain
• Dynein heavy chain, C-terminal domain, barrel region
• Dynein heavy chain region D6 P-loop domain
• Dynein heavy chain, N-terminal region 2
• Hydrolytic ATP binding site of dynein motor region
• P-loop containing dynein motor region
• P-loop containing dynein motor region D4
• Dynein heavy chain AAA lid domain
• AAA+ lid domain
• Dynein heavy chain AAA lid domain
• Dynein heavy chain C-terminal domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Cilium
• Coiled coil
• Developmental protein
• Dynein
• Flagellum
• Microtubule
• Motor protein
• Nucleotide-binding
• Repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of DNAH12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DNAH1
• RSPH1
• RSPH9
• DNAJB13