ABCG1

Protein identityUniProt · HPA

UniProt accession

P45844

Gene

ABCG1

Ensembl

ENSG00000160179

Chromosome

21

Canonical length

678 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Golgi apparatus,Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>P45844|ABCG1
     1  MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL
    61  TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS
   121  GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV
   181  SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF
   241  DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK
   301  VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD
   361  AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS
   421  VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE
   481  MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL
   541  GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS
   601  YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI
   661  SLRLIAYFVL RYKIRAER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

36 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.11

gnomAD missense Z

2.13

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid precursor protein catabolic process
• cellular response to high density lipoprotein particle stimulus
• cholesterol efflux
• cholesterol homeostasis
• cholesterol metabolic process
• glycoprotein transport
• high-density lipoprotein particle remodeling
• intracellular cholesterol transport
• low-density lipoprotein particle remodeling
• negative regulation of cholesterol storage
• negative regulation of macrophage derived foam cell differentiation
• phospholipid efflux
• phospholipid homeostasis
• positive regulation of amyloid-beta formation
• positive regulation of cholesterol biosynthetic process
• positive regulation of cholesterol efflux
• positive regulation of protein secretion
• regulation of cholesterol metabolic process
• response to lipid
• reverse cholesterol transport
• transmembrane transport
• xenobiotic detoxification by transmembrane export across the plasma membrane

Molecular functions

• ABC-type sterol transporter activity
• ADP binding
• ATP binding
• ATP hydrolysis activity
• cholesterol binding
• cholesterol transfer activity
• floppase activity
• phosphatidylcholine floppase activity
• phospholipid binding
• protein heterodimerization activity
• protein homodimerization activity
• toxin transmembrane transporter activity

Cellular components

• endoplasmic reticulum membrane
• endosome
• external side of plasma membrane
• Golgi apparatus
• Golgi membrane
• mitochondrion
• nucleoplasm
• plasma membrane
• recycling endosome

Protein domainsUniProt · Pfam · InterPro

• ABC transporter-like, ATP-binding domain
• AAA+ ATPase domain
• ABC-2 type transporter, transmembrane domain
• ABC transporter-like, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• ABC transporter family G domain
• ATP-binding cassette subfamily G transporters
• ABC transporter
• ABC-2 type transporter
• ABC-2 type transporter
• Pigment precursor permease/Protein ATP-binding cassette sub-family G

KeywordsUniProt

• ATP-binding
• Cell membrane
• Endoplasmic reticulum
• Golgi apparatus
• Lipid transport
• Lipoprotein
• Membrane
• Nucleotide-binding
• Palmitate
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ABCG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAV1