Seroatlas · Human Serome Atlas

HS6ST3

Heparan-sulfate 6-O-sulfotransferase 3

Also known as: H6ST3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZP7
Gene
HS6ST3
Ensembl
ENSG00000185352
Chromosome
13
Canonical length
471 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Plasma membrane,Actin filaments

OverviewNCBI Gene

Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q8IZP7|HS6ST3
     1  MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA VPGPARRAQA
    61  PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE GEEEEEEDEP DPEAPENGSL
   121  PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG
   181  QKKCTCHRPG KKETWLFSRF STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY
   241  ITMLRDPVSR YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD
   301  CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF FGLTEFQRKT
   361  QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL NFLDMQLYEY AKDLFQQRYH
   421  HTKQLEHQRD RQKRREERRL QREHRDHQWP KEDGAAEGTV TEDYNSQVVR W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HS6ST3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 16 nTPM
  • hippocampal formation: 10 nTPM
  • hypothalamus: 6.6 nTPM
  • blood vessel: 6.1 nTPM
  • basal ganglia: 5.4 nTPM
  • amygdala: 5 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 1,363 nCPM
  • adrenal medulla cells: 1,362 nCPM
  • retinal ganglion cells: 1,317 nCPM
  • brain excitatory neurons: 1,267 nCPM
  • pancreatic islet cells: 1,236 nCPM
  • bergmann glia: 1,233 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 45 nTPM
  • cerebral cortex: 38 nTPM
  • hypothalamus: 32 nTPM
  • midbrain: 30 nTPM
  • thalamus: 23 nTPM
  • basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
1.19
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HS6ST3 as an antibody target. Whether an autoantibody or antibody against HS6ST3 could matter depends on whether native HS6ST3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HS6ST3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HS6ST3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HS6ST3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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