Seroatlas · Human Serome Atlas

GIMD1

GTPase IMAP family member GIMD1

Also known as: GIMD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DJR0
Gene
GIMD1
Ensembl
ENSG00000250298
Chromosome
4
Canonical length
217 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P0DJR0|GIMD1
     1  MTDPNKMIIN LALFGMTQSG KSSAGNILLG STDFHSSFAP CSVTTCCSLG RSCHLHSFMR
    61  RGGLEVALQV QVLDTPGYPH SRLSKKYVKQ EVKEALAHHF GQGGLHLALL VQRADVPFCG
   121  QEVTDPVQMI QELLGHAWMN YTAILFTHAE KIEEAGLTED KYLHEASDTL KTLLNSIQHK
   181  YVFQYKKGKS LNEQRMKILE RIMEFIKENC YQVLTFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 26 nTPM
  • small intestine: 15 nTPM
  • gallbladder: 2.8 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • thymocytes: 1.7 nCPM
  • schwann cells: 1 nCPM
  • endometrial stromal cells: 0.5 nCPM
  • enterocytes: 0.5 nCPM
  • mast cells: 0.3 nCPM
  • mesothelial cells: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMD1 as an antibody target. Whether an autoantibody or antibody against GIMD1 could matter depends on whether native GIMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GIMD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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