RAB32

Protein identityUniProt · HPA

UniProt accession

Q13637

Gene

RAB32

Ensembl

ENSG00000118508

Chromosome

6

Canonical length

225 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q13637|RAB32
     1  MAGGGAGDPG LGAAAAPAPE TREHLFKVLV IGELGVGKTS IIKRYVHQLF SQHYRATIGV
    61  DFALKVLNWD SRTLVRLQLW DIAGQERFGN MTRVYYKEAV GAFVVFDISR SSTFEAVLKW
   121  KSDLDSKVHL PNGSPIPAVL LANKCDQNKD SSQSPSQVDQ FCKEHGFAGW FETSAKDNIN
   181  IEEAARFLVE KILVNHQSFP NEENDVDKIK LDQETLRAEN KSQCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

165 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB32.

Disease | AllUniProt

Conditions RAB32 is implicated in, by any mechanism.

• Parkinson disease 26, autosomal dominant (PARK26) MIM:620923

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.29

gnomAD pLI

0

gnomAD missense Z

-0.26

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antigen processing and presentation
• endosome to melanosome transport
• intracellular protein transport
• melanosome assembly
• melanosome organization
• mitochondrion organization
• phagosome maturation
• protein localization to membrane
• vesicle-mediated transport

Molecular functions

• AP-1 adaptor complex binding
• AP-3 adaptor complex binding
• BLOC-2 complex binding
• G protein activity
• GTP binding
• GTP-dependent protein binding
• GTPase activity

Cellular components

• cytosol
• early endosome
• endomembrane system
• endoplasmic reticulum
• melanosome
• melanosome membrane
• membrane
• mitochondria-associated endoplasmic reticulum membrane contact site
• mitochondrial outer membrane
• mitochondrion
• phagocytic vesicle
• phagocytic vesicle membrane
• trans-Golgi network

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Ras-related protein Rab29/Rab38/Rab32
• Ras family

KeywordsUniProt

• Acetylation
• Cytoplasmic vesicle
• GTP-binding
• Hydrolase
• Lipoprotein
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Nucleotide-binding
• Parkinson disease
• Parkinsonism
• Phosphoprotein
• Prenylation

InteractionsUniProt · HPA

Protein binding partners of RAB32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANKRD27
• LRRK2