Seroatlas · Human Serome Atlas

N4BP2L2

NEDD4-binding protein 2-like 2

Also known as: CG005, N42L2_HUMAN, PFAAP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92802
Gene: N4BP2L2
Ensembl: ENSG00000244754
Chromosome: 13
Canonical length: 583 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q92802|N4BP2L2
     1  MSYGEIEGKF LGPREEVTSE PRCKKLKSTT ESYVFHNHSN ADFHRIQEKT GNDWVPVTII
    61  DVRGHSYLQE NKIKTTDLHR PLHDEMPGNR PDVIESIDSQ VLQEARPPLV SADDEIYSTS
   121  KAFIGPIYKP PEKKKRNEGR NEAHVLNGIN DRGGQKEKQK FNSEKSEIDN ELFQFYKEIE
   181  ELEKEKDGFE NSCKESEPSQ EQFVPFYEGH NNGLLKPDEE KKDLSNKAMP SHCDYQQNLG
   241  NEPDKYPCNG QVIPTFCDTS FTSFRPEWQS VYPFIVPYGP PLPSLNYHLN IQRFSGPPNP
   301  PSNIFQAQDD SQIQNGYYVN NCHVNWNCMT FDQNNEYTDC SENRSSVHPS GNGCSMQDRY
   361  VSNGFCEVRE RCWKDHCMDK HNGTDRFVNQ QFQEEKLNKL QKLLILLRGL PGSGKTTLSR
   421  ILLGQNRDGI VFSTDDYFHH QDGYRYNVNQ LGDAHDWNQN RAKQAIDQGR SPVIIDNTNI
   481  QAWEMKPYVE VAIGKGYRVE FHEPETWWKF DPEELEKRNK HGVSRKKIAQ MLDRYEYQMS
   541  ISIVMNSVEP SHKSTQRPPP PQGRQRWGGS LGSHNRVCVT NNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against N4BP2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 61 nTPM
tongue: 57 nTPM
ovary: 44 nTPM
choroid plexus: 40 nTPM
heart muscle: 40 nTPM
blood vessel: 39 nTPM

Single-cell type

myonuclei: 1,848 nCPM
choroid plexus epithelial cells: 880 nCPM
neutrophils: 777 nCPM
somatotrophs: 774 nCPM
pituicytes/fscs: 772 nCPM
lactotrophs: 766 nCPM

Immune cell

basophil: 35 nTPM
eosinophil: 29 nTPM
MAIT T-cell: 24 nTPM
naive CD4 T-cell: 23 nTPM
non-classical monocyte: 23 nTPM
NK-cell: 21 nTPM

Brain region

cerebellum: 74 nTPM
white matter: 68 nTPM
basal ganglia: 60 nTPM
cerebral cortex: 57 nTPM
spinal cord: 55 nTPM
amygdala: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about N4BP2L2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 39 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads N4BP2L2 as an antibody target. Whether an autoantibody or antibody against N4BP2L2 could matter depends on whether native N4BP2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

N4BP2L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label N4BP2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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