NLRP13

Protein identityUniProt · HPA

UniProt accession

Q86W25

Gene

NLRP13

Ensembl

ENSG00000173572

Chromosome

19

Canonical length

1043 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

1043 residues, UniProt reviewed canonical sequence.

>Q86W25|NLRP13
     1  MNFSVITCPN GGTNQGLLPY LMALDQYQLE EFKLCLEPQQ LMDFWSAPQG HFPRIPWANL
    61  RAADPLNLSF LLDEHFPKGQ AWKVVLGIFQ TMNLTSLCEK VRAEMKENVQ TQELQDPTQE
   121  DLEMLEAAAG NMQTQGCQDP NQEELDELEE ETGNVQAQGC QDPNQEEPEM LEEADHRRKY
   181  RENMKAELLE TWDNISWPKD HVYIRNTSKD EHEELQRLLD PNRTRAQAQT IVLVGRAGVG
   241  KTTLAMQAML HWANGVLFQQ RFSYVFYLSC HKIRYMKETT FAELISLDWP DFDAPIEEFM
   301  SQPEKLLFII DGFEEIIISE SRSESLDDGS PCTDWYQELP VTKILHSLLK KELVPLATLL
   361  ITIKTWFVRD LKASLVNPCF VQITGFTGDD LRVYFMRHFD DSSEVEKILQ QLRKNETLFH
   421  SCSAPMVCWT VCSCLKQPKV RYYDLQSITQ TTTSLYAYFF SNLFSTAEVD LADDSWPGQW
   481  RALCSLAIEG LWSMNFTFNK EDTEIEGLEV PFIDSLYEFN ILQKINDCGG CTTFTHLSFQ
   541  EFFAAMSFVL EEPREFPPHS TKPQEMKMLL QHVLLDKEAY WTPVVLFFFG LLNKNIAREL
   601  EDTLHCKISP RVMEELLKWG EELGKAESAS LQFHILRLFH CLHESQEEDF TKKMLGRIFE
   661  VDLNILEDEE LQASSFCLKH CKRLNKLRLS VSSHILERDL EILETSKFDS RMHAWNSICS
   721  TLVTNENLHE LDLSNSKLHA SSVKGLCLAL KNPRCKVQKL TCKSVTPEWV LQDLIIALQG
   781  NSKLTHLNFS SNKLGMTVPL ILKALRHSAC NLKYLCLEKC NLSAASCQDL ALFLTSIQHV
   841  TRLCLGFNRL QDDGIKLLCA ALTHPKCALE RLELWFCQLA APACKHLSDA LLQNRSLTHL
   901  NLSKNSLRDE GVKFLCEALG RPDGNLQSLN LSGCSFTREG CGELANALSH NHNVKILDLG
   961  ENDLQDDGVK LLCEALKPHR ALHTLGLAKC NLTTACCQHL FSVLSSSKSL VNLNLLGNEL
  1021  DTDGVKMLCK ALKKSTCRLQ KLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

1.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

-1.57

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of inflammatory response

Molecular functions

• ATP binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• DAPIN domain
• NACHT nucleoside triphosphatase
• Death-like domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NOD1/2, winged helix domain
• NACHT, LRR and PYD domains-containing protein, helical domain HD2
• NLRP family, innate immunity and inflammation regulators
• Leucine Rich Repeat
• PAAD/DAPIN/Pyrin domain
• NACHT domain
• Leucine Rich repeat
• NLRC4 helical domain HD2
• NOD2 winged helix domain

KeywordsUniProt

• ATP-binding
• Leucine-rich repeat
• Nucleotide-binding
• Repeat